Evidence map›Paper›PMID 38484963›Full record

ArticleAmerican heart journal2024

Vascular health years after a hypertensive disorder of pregnancy: The EPOCH study.

Hayley E Miller, Seda Tierney, Marcia L Stefanick, Jonathan A Mayo, Oshra Sedan, Lisa G Rosas, Mads Melbye, Heather A Boyd, David K Stevenson, Gary M Shaw and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Hayley E MillerDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
Seda TierneyDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Marcia L StefanickDepartment of Medicine, Stanford University School of Medicine, Stanford, CA; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
Jonathan A MayoDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Oshra SedanDepartment of Health Policy, Stanford University School of Medicine, Stanford, CA.
Lisa G RosasDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA; Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Mads MelbyeDanish Cancer Institute, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Heather A BoydDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Gary M ShawDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Virginia D WinnDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.
Mark A HlatkyDepartment of Health Policy, Stanford University School of Medicine, Stanford, CA; Department of Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address: hlatky@stanford.edu.
Stanford University · USStanford Medicine · USStatens Serum Institut · DKUniversity of Copenhagen · DK

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Preeclampsia to cardiovascular disease: Life course analysis of biomarkers and riskR01HL139844 · NHLBI · STANFORD UNIVERSITY · PI HLATKY, MARK A., WINN, VIRGINIA D · 2018 to 2021
$9.0M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NHLBI NIH HHS R01 HL139844
6 · The paper itself

Abstract

backgroundPreeclampsia is associated with a two-fold increase in a woman's lifetime risk of developing atherosclerotic cardiovascular disease (ASCVD), but the reasons for this association are uncertain. The objective of this study was to examine the associations between vascular health and a hypertensive disorder of pregnancy among women ≥ 2 years postpartum.

methodsPre-menopausal women with a history of either a hypertensive disorder of pregnancy (cases: preeclampsia or gestational hypertension) or a normotensive pregnancy (controls) were enrolled. Participants were assessed for standard ASCVD risk factors and underwent vascular testing, including measurements of blood pressure, endothelial function, and carotid artery ultrasound. The primary outcomes were blood pressure, ASCVD risk, reactive hyperemia index measured by EndoPAT and carotid intima-medial thickness. The secondary outcomes were augmentation index normalized to 75 beats per minute and pulse wave amplitude measured by EndoPAT, and carotid elastic modulus and carotid beta-stiffness measured by carotid ultrasound.

resultsParticipants had a mean age of 40.7 years and were 5.7 years since their last pregnancy. In bivariate analyses, cases (N = 68) were more likely than controls (N = 71) to have hypertension (18% vs 4%, P = .034), higher calculated ASCVD risk (0.6 vs 0.4, P = .02), higher blood pressures (systolic: 118.5 vs 111.6 mm Hg, P = .0004; diastolic: 75.2 vs 69.8 mm Hg, P = .0004), and higher augmentation index values (7.7 vs 2.3, P = .03). They did not, however, differ significantly in carotid intima-media thickness (0.5 vs 0.5, P = .29) or reactive hyperemia index (2.1 vs 2.1, P = .93), nor in pulse wave amplitude (416 vs 326, P = .11), carotid elastic modulus (445 vs 426, P = .36), or carotid beta stiffness (2.8 vs 2.8, P = .86).

conclusionWomen with a prior hypertensive disorder of pregnancy had higher ASCVD risk and blood pressures several years postpartum, but did not have more endothelial dysfunction or subclinical atherosclerosis.

Indexed as

Carotid Intima-Media ThicknessHypertension, Pregnancy-InducedVascular StiffnessAdultAtherosclerosisBlood PressureCarotid ArteriesCase-Control StudiesEndothelium, VascularFemaleHumansPre-EclampsiaPregnancyPulse Wave AnalysisRisk Factors

Identifiers

PMID38484963
PMCPMC11070303
OpenAlexW4392710942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.