Evidence map›Paper›PMID 38484747›Full record

ArticleThe Lancet. Respiratory medicine2024

Charting a course for precision therapy trials in sepsis.

Robert B Lindell, Nuala J Meyer

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Lancet. Respiratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Robert B LindellDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nuala J MeyerInstitute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Translational Lung Biology, Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: nuala.meyer@pennmedicine.upenn.edu.

Funding

Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress SyndromeR35HL161196 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Nuala Jennings Meyer · 2022 to 2026
$4.8M
PediAtric ReseArch of Drugs, Immunoparalysis and Genetics during MODS (PARADIGM)R01HD095976 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2019 to 2023
$3.4M
Transfusion and Organ Dysfunction in Pediatric Septic Shock (TROPICS) studyR01HL157208 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Jennifer Muszynski · 2022 to 2026
$3.4M
Vascular mechanisms of sepsis-induced cognitive dysfunctionR01HL168892 · NHLBI · OHIO STATE UNIVERSITY · PI Paco S Herson, Eric Peter Schmidt · 2023 to 2026
$2.8M
Phenotyping ARDS, Pneumonia, and Sepsis over time to elucidate shared and distinct trajectories ofillness and recoveryU01HL168419 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Michael Oscar Harhay, Nuala Jennings Meyer · 2023 to 2026
$1.8M
Pediatric Sepsis Biorepository and Clinical DatabaseR21GM146159 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI BALAMUTH, FRANCES B, SANCHEZ-PINTO, LAZARO NELSON · 2022 to 2023
$478k
Targeting Immune Dysregulated Endotypes in Sepsis (TIDES)K23GM159013 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert B Lindell · 2025 to 2026
$359k
NHLBI NIH HHS R01 HL157208NHLBI NIH HHS R01 HL168892NHLBI NIH HHS R35 HL161196NHLBI NIH HHS U01 HL168419NICHD NIH HHS K12 HD047349NICHD NIH HHS R01 HD095976NIGMS NIH HHS K23 GM159013NIGMS NIH HHS R21 GM146159
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Precision MedicineSepsisHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.