Evidence map›Paper›PMID 38484742›Full record

ArticleJournal of proteome research2024

Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography-Mass Spectrometry (LC-MS).

Luke Whiley, Nathan G Lawler, Annie Xu Zeng, Alex Lee, Sung-Tong Chin, Maider Bizkarguenaga, Chiara Bruzzone, Nieves Embade, Julien Wist, Elaine Holmes and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of proteome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.Metabolomics : Official journal of the Metabolomic Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 4 countries.

Luke WhileyAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-9088-4799
Nathan G LawlerAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0001-9649-425X
Annie Xu ZengAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.
Alex LeeAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-0355-7248
Sung-Tong ChinAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.
Maider BizkarguenagaCentro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain.
Chiara BruzzoneCentro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain.ORCID 0000-0003-4252-8180
Nieves EmbadeCentro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain.ORCID 0000-0001-9878-3290
Julien WistAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-3416-2572
Elaine HolmesAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-0556-8389
Oscar MilletCentro de Investigación Cooperativa en Biociencias─CIC bioGUNE, Precision Medicine and Metabolism Laboratory, Basque Research and Technology Alliance, Bizkaia Science and Technology Park, Building 800, 48160 Derio, Spain.ORCID 0000-0001-8748-4105
Jeremy K NicholsonAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-8123-8349
Nicola GrayAustralian National Phenome Centre, Health Futures Institute Harry Perkins Institute, Murdoch University, 5 Robin Warren Drive, Perth, WA 6150, Australia.ORCID 0000-0002-0094-5245
Murdoch University · AUEuskadiko Parke Teknologikoa · ES

Funding

Medical Research Council
6 · The paper itself

Abstract

To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. We evaluated the capability of liquid chromatography-mass spectrometry (LC-MS) assays targeting organic acids and bile acids to validate metabolic phenotypes of SARS-CoV-2 infection. Two independent sample sets were collected: (1) Australia: plasma, SARS-CoV-2 positive (

Indexed as

COVID-19SARS-CoV-2Bile Acids and SaltsChromatography, LiquidHumansLiquid Chromatography-Mass SpectrometryPhenotypeTandem Mass SpectrometryBile Acids and Saltsbile acidsCOVID-19hypoxiaLC-MSmetabolic phenotypingmetabolic phenotyping arrayorganic acidsoxidative stressSARS-CoV-2TCA cyclevalidation

Identifiers

PMID38484742
PMCPMC11002931
OpenAlexW4392791829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.