SynthesisClinics (Sao Paulo, Brazil)2024
Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis.
Synthesis in Clinics (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparative screening accuracy of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-Chat-R/F) for early autism spectrum disorder: a systematic review.Family medicine and community health · 2026Pooled it
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Behavioral therapies for the treatment of autism spectrum disorder: A systematic review.Clinics (Sao Paulo, Brazil) · 2025Pooled it
- Classification of neurodevelopmental disorders and typical development using deep learning and a portable patch-type electroencephalography device.Neuroimage. Reports · 2026Article
- NeuroCypher ASD: Machine Learning with Knowledge Graph-Based Representation for ASD Screening in Toddlers.Journal of healthcare informatics research · 2026Article
- Examining Sociodemographic Factors Related to Autism Screening Rates of Children in Early Intervention.Journal of autism and developmental disorders · 2025Article
- Association between GRIK1 rs363598 and intergenic rs360932 variants and susceptibility to autism spectrum disorders in Egyptian children.BMC pediatrics · 2025Article
- National assessment of early intervention services for children with developmental disorders in Lithuania: A mixed-methods study on gaps and future directions.European journal of pediatrics · 2025Article
- Assessment of psychometric properties of autism spectrum diagnostic profile (ASDP) among Egyptian children aged 2-12 years.BMC psychiatry · 2025Article
- Review
- Autism, Diagnostics, and Dementia: A Consensus Report From the 2nd International Summit on Intellectual Disabilities and Dementia.International journal of geriatric psychiatry · 2025Review
- Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1-12 years.Molecular autism · 2025Article
- Cognitive Brain Networks and Enlarged Perivascular Spaces: Implications for Symptom Severity and Support Needs in Children with Autism.Journal of clinical medicine · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
- The global prevalence of autism spectrum disorder in children: a systematic review and meta-analysis.Osong public health and research perspectives · 2025Article
- AI-assisted early screening, diagnosis, and intervention for autism in young children.Frontiers in psychiatry · 2025Review
- HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members.Microorganisms · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAutism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder, with main manifestations related to communication, social interaction, and behavioral patterns. The slight dynamics of change in the child over time require that the onset of clinical manifestations presented by the child be more valued, with the aim of stabilizing the condition. Faced with a variety of methods for diagnosing ASD, the question arises as to which method should be used. This systematic review aims to recommend the best tools to perform screening and diagnosis. METHODOLOGY: This systematic review followed the PRISMA guidelines. The databases MEDLINE, Embase, CENTRAL (Cochrane), and Lilacs were accessed, and gray and manual searches were performed. The search strategy was created with terms referring to autism and the diagnosis/broad filter. The studies were qualitatively evaluated and quantitatively. Statistical analysis was performed using Meta-diSc-2.0 software, the confidence interval was 95 %.
resultsThe M-CHAT-R/F tool demonstrated a sensitivity of 78 % (95 % CI 0.57‒0.91) and specificity of 0.98 (95 % CI 0.88-1.00). The diagnostic tools demonstrated sensitivity and specificity respectively of: ADOS, sensitivity of 87 % (95 % CI 0.79‒0.92) and specificity 75 % (95 % CI 0.73‒0.78); ADI-R demonstrated test sensitivity of 77 % (95 % CI 0.56‒0.90) and specificity 68 % (95 % CI 0.52‒0.81), CARS test sensitivity was 89 % (95 % CI 0.78‒0.95) and specificity 79 % (95 % CI 0.65‒0.88).
conclusionIt is mandatory to apply a screening test, the most recommended being the M-CHAT-R/F. For diagnosis CARS and ADOS are the most recommended tools.
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