Evidence map›Paper›PMID 38484034›Full record

ReviewCirculation research2024

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure.

Frank M Faraci, Frank A J L Scheer

Open access · greenAbstract readReview
In one paragraph

Review in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  4. Time-varying eating behaviors and long-term risk of incident hypertension in a Japanese cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  10. Exploring the Linear and Non-linear Association Between BMI and Night-Time Blood Pressure Variability.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  11. Article
  12. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Frank M FaraciDepartment of Internal Medicine (F.M.F.), Francois M. Abboud Cardiovascular Center, Carver College of Medicine, University of Iowa.ORCID 0000-0002-0203-1690
Frank A J L ScheerDivision of Sleep Medicine, Harvard Medical School, Boston, MA (F.A.J.L.S.).ORCID 0000-0002-2014-7582
Brigham and Women's Hospital · USCentre François Baclesse · LU

Funding

Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2021 to 2025
$3.9M
Effect of high fat diet on the circadian system and on circadian rhythms in energy intake and expenditureR01HL167746 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FRANK A SCHEER · 2023 to 2026
$3.2M
Effect of temporal distribution of macronutrient intake on metabolismR01HL164454 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FRANK A SCHEER · 2023 to 2026
$3.2M
Central RAAS and Brain Small Vessel DiseaseR01NS108409 · NINDS · UNIVERSITY OF IOWA · PI FARACI, FRANK M · 2018 to 2022
$2.5M
NHLBI NIH HHS R01 HL153969NHLBI NIH HHS R01 HL164454NHLBI NIH HHS R01 HL167746NINDS NIH HHS R01 NS108409
6 · The paper itself

Abstract

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

Indexed as

Cardiovascular DiseasesHypertensionAdultBlood PressureCircadian RhythmHeartHumansblood pressurecerebrovascular circulationcircadian rhythmendotheliumstroke

Identifiers

PMID38484034
PMCPMC10947115
OpenAlexW4392796853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.