Evidence map›Paper›PMID 38484029›Full record

ReviewCirculation research2024

Circadian Rhythms in Cardiovascular Metabolism.

Hind Lal, Suresh Kumar Verma, Yajing Wang, Min Xie, Martin E Young

Abstract readReview
In one paragraph

Review in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  20. Circadian rhythms in cardiovascular disease.European heart journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hind LalDivision of Cardiovascular Disease, Department of Medicine (H.L., S.K.V., M.X., M.E.Y.), University of Alabama at Birmingham.ORCID 0000-0001-8980-9874
Suresh Kumar VermaDivision of Cardiovascular Disease, Department of Medicine (H.L., S.K.V., M.X., M.E.Y.), University of Alabama at Birmingham.
Yajing WangDepartment of Biomedical Engineering (Y.W.), University of Alabama at Birmingham.ORCID 0000-0002-6358-6948
Min XieDivision of Cardiovascular Disease, Department of Medicine (H.L., S.K.V., M.X., M.E.Y.), University of Alabama at Birmingham.ORCID 0000-0002-2967-3490
Martin E YoungDivision of Cardiovascular Disease, Department of Medicine (H.L., S.K.V., M.X., M.E.Y.), University of Alabama at Birmingham.ORCID 0000-0001-8360-5029

Funding

Targeting Adiponectin for Cardioprotection in the Ischemic HeartR01HL096686 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG, WANG, YAJING · 2010 to 2024
$4.7M
Signaling Mechanisms Governing Myocardial Fibrosis in Diseased HeartR01HL133290 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Hind Lal · 2017 to 2026
$3.6M
Project-002R01HL143074 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hind Lal · 2019 to 2026
$3.4M
Cav-3 in Diabetic Myocardial Injury Following Ischemia/ReperfusionR01HL123404 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG · 2015 to 2023
$2.7M
Dysregulated Adiponectin Transmembrane Signaling in Diabetic CoronaryVascular Injury and Heart FailureR01HL157495 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2022 to 2025
$2.3M
IL10 REGULATION OF FIBROBLAST PROGENITOR CELL MEDIATED CARDIAC FIBROSISR01HL135060 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VERMA, SURESH K · 2017 to 2021
$1.9M
Metabolic Rhythm Alterations as a Cause for Obesity CardiomyopathyR01HL149159 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2019 to 2022
$1.9M
Novel strategies to mitigate cardiac damage and dysfunction following invasive pneumococcal diseaseR01HL171136 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hind Lal, Carlos J Orihuela · 2024 to 2026
$1.8M
Critical Role of Small Extracellular Vesicles in Diabetic Coronary VascularDysfunction and Diabetic Ischemic Heart Failure effortsR01HL158612 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2021 to 2024
$1.5M
Circadian Regulation of mTOR Signaling in the Failing HeartF32HL154531 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LATIMER, MARY NESLUND · 2020 to 2020
$65k
American Heart Association-American Stroke Association 958292NHLBI NIH HHS F32 HL154531NHLBI NIH HHS R01 HL096686NHLBI NIH HHS R01 HL123404NHLBI NIH HHS R01 HL133290NHLBI NIH HHS R01 HL135060NHLBI NIH HHS R01 HL143074NHLBI NIH HHS R01 HL149159NHLBI NIH HHS R01 HL157495NHLBI NIH HHS R01 HL158612NHLBI NIH HHS R01 HL171136
6 · The paper itself

Abstract

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become increasingly clear is that in addition to classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks to temporally orchestrate metabolic pathways in preparation for predicted stimuli/stresses (termed anticipatory mechanisms). Here, we review current knowledge regarding circadian regulation of metabolism, how metabolic rhythms are synchronized with cardiovascular function, and whether circadian misalignment/disruption of metabolic processes contribute toward the pathogenesis of cardiovascular disease.

Indexed as

Circadian ClocksCircadian RhythmHeartMyocardiumSleepblood pressurecardiovascular diseasescircadian clocksmetabolismsleep

Identifiers

PMID38484029
PMCPMC10947116

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.