Evidence map›Paper›PMID 38483657›Full record

ArticleMolecular neurobiology2024

Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H

Shaojun Wu, Jie Miao, Susu Zhu, Xinyuan Wu, Jindan Shi, Jichao Zhou, Yi Xing, Kun Hu, Jie Ren, Hao Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Ethyl Acetate Extract ofCurrent issues in molecular biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shaojun WuSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Jie MiaoSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Susu ZhuSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Xinyuan WuSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Jindan ShiSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Jichao ZhouSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Yi XingSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Kun HuSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China.
Jie RenSchool of Pharmacy, Changzhou University, No. 1. Gehu Middle Road, Changzhou, 213164, Jiangsu, China. renjie2006@163.com.
Hao YangDepartment of Pharmacy, the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, No. 68. Gehu Middle Road, Changzhou, 213164, Jiangsu, China. yanghao9549@163.com.
Changzhou University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite tremendous advances in modern medicine, effective prevention or therapeutic strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) remain limited. Growing evidence now suggests that oxidative stress and apoptosis are increasingly associated with AD as promising therapeutic targets. Pongamol, a flavonoid, is the main constituent of pongamia pinnata and possesses a variety of pharmacological activities such as antioxidant, anti-aging and anti-inflammatory. In the present study, we investigated the antioxidant effects and mechanisms of pongamol in H

Indexed as

Caenorhabditis elegansHydrogen PeroxideLongevityNeuronsNF-E2-Related Factor 2AnimalsAntioxidantsApoptosisFlavonesMAP Kinase Signaling SystemNeuroprotective AgentsOxidative StressPC12 CellsRatsReactive Oxygen SpeciesSignal TransductionAntioxidantsFlavonesHydrogen PeroxideNeuroprotective AgentsNF-E2-Related Factor 2Reactive Oxygen SpeciesAlzheimer’s diseaseApoptosisMAPKs/Nrf2 signaling pathwayOxidative stressPongamol

Identifiers

PMID38483657
OpenAlexW4392799093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.