Evidence map›Paper›PMID 38483655›Full record

ArticleMolecular neurobiology2024

Antitumoral Activity of Cecropia Pachystachya Leaves Extract in Vitro and in Vivo Model of Rat Glioma: Brain and Blood Effects.

Natália Pontes Bona, Nathalia Stark Pedra, Luiza Spohr, Francieli da Silva Dos Santos, Juliane Torchelsen Saraiva, Fabiano Barbosa Carvalho, Marilda da Cruz Fernandes, Ana Sofia Fernandes, Nuno Saraiva, Marta Filipa Martins and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Kinin BPharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Natália Pontes BonaPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, 96010-900, Brazil.ORCID http://orcid.org/0000-0001-5944-1968
Nathalia Stark PedraPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.ORCID http://orcid.org/0000-0001-8662-7661
Luiza SpohrPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.ORCID http://orcid.org/0000-0003-1587-1880
Francieli da Silva Dos SantosPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, 96010-900, Brazil.ORCID http://orcid.org/0009-0002-9887-8825
Juliane Torchelsen SaraivaPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, 96010-900, Brazil.ORCID http://orcid.org/0009-0008-7124-5183
Fabiano Barbosa CarvalhoLaboratório de Pesquisa em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-7927-1342
Marilda da Cruz FernandesLaboratório de Pesquisa em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0003-4234-797X
Ana Sofia FernandesCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisboa, 1749-024, Portugal.ORCID http://orcid.org/0000-0001-6350-0641
Nuno SaraivaCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisboa, 1749-024, Portugal.ORCID http://orcid.org/0000-0003-1333-9137
Marta Filipa MartinsCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisboa, 1749-024, Portugal.ORCID http://orcid.org/0000-0003-4758-3031
Rejane Giacomelli TavaresCBIOS, Universidade Lusófona's Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisboa, 1749-024, Portugal.ORCID http://orcid.org/0000-0002-9806-1893
Roselia Maria SpanevelloPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.ORCID http://orcid.org/0000-0002-5117-2000
Mayara Sandrielly Soares de AguiarPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil.ORCID http://orcid.org/0000-0002-2181-3591
Francieli Moro StefanelloPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, 96010-900, Brazil. francieli.stefanello@ufpel.edu.br.ORCID http://orcid.org/0000-0001-5945-3723
Universidade Federal de Pelotas · BRUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Lusófona · PTUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the antiglioma effect of Cecropia pachystachya Trécul (CEC) leaves extract against C6 and U87 glioblastoma (GB) cells and in a rat preclinical GB model. The CEC extract reduced in vitro cell viability and biomass. In vivo, the extract decreased the tumor volume approximately 62%, without inducing systemic toxicity. The deficit in locomotion and memory and an anxiolytic-like behaviors induced in the GB model were minimized by CEC. The extract decreased the levels of reactive oxygen species, nitrites and thiobarbituric acid reactive substances and increased the activity of antioxidant enzymes in platelets, sera and brains of GB animals. The activity of NTPDases, 5'-nucleotidase and adenosine deaminase (ADA) was evaluated in lymphocytes, platelets and serum. In platelets, ATP and AMP hydrolysis was reduced and hydrolysis of ADP and the activity of ADA were increased in the control, while in CEC-treated animals no alteration in the hydrolysis of ADP was detected. In serum, the reduction in ATP hydrolysis was reversed by CEC. In lymphocytes, the increase in the hydrolysis of ATP, ADP and in the activity of ADA observed in GB model was altered by CEC administration. The observed increase in IL-6 and decrease in IL-10 levels in the serum of GB animals was reversed by CEC. These results demonstrate that CEC extract is a potential complementary treatment to GB, decreasing the tumor size, while modulating aspects of redox and purinergic systems.

Indexed as

Cecropia PlantGliomaPlant ExtractsPlant LeavesRats, Wistar5'-NucleotidaseAdenosine DeaminaseAnimalsAntineoplastic Agents, PhytogenicAntioxidantsBrainBrain NeoplasmsCell Line, TumorCell SurvivalDisease Models, AnimalMale5'-NucleotidaseAdenosine DeaminaseAntineoplastic Agents, PhytogenicAntioxidantsPlant ExtractsReactive Oxygen SpeciesCecropia pachystachyaGlioblastomaNatural productPurinergic systemRedox statusToxicity

Identifiers

PMID38483655
OpenAlexW4392808360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.