ArticleVirchows Archiv : an international journal of pathology2024
Epidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features.
Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 0 citations in OpenAlex.
- Epidermodysplasia verruciformis-associated eccrine neoplasm: morphologic and immunohistochemical characterization of 25 lesions in two patients.Virchows Archiv : an international journal of pathology · 2026Article
- Distinct molecular pathogenesis in the two most common subtypes of cutaneous squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2026Article
- A Holistic Bibliometric Exploration of the Evolution of Epidermodysplasia Verruciformis (EV) Research.Advanced biomedical research · 2026Article
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6 authors at 1 institution in 1 country.
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Abstract
Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection including Kaposi sarcoma, nasopharyngeal carcinoma, and others. Human papillomavirus (HPV) is an especially common cause of epithelial cancers and hyperplasias. Epidermodysplasia verruciformis (EDV) is a rare type of HPV infection with characteristic histopathologic features and a unique spectrum of HPV subtypes. We report here a distinctive form of EDV-associated eccrine neoplasia. Seven tumors from two patients were analyzed and show highly uniform features including multiple clustered clinical lesions, multifocal epidermal origin, eccrine differentiation with close association with the acrosyringium, an anastomosing growth pattern, and a bland monotonous poroid-to-basaloid cytomorphology. Clinical follow-up for one patient has been benign to date. These tumors show strong similarity to two previously reported cases, suggesting that this type of EDV-associated eccrine neoplasia may represent a rare but reproducible form of skin adnexal tumor with distinctive clinicopathologic features.
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