ArticleSocial psychiatry and psychiatric epidemiology2024
Testing a syndemics perspective on the effects of multiple adversities on depression and anxiety symptoms in a representative population sample.
Article in Social psychiatry and psychiatric epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Lifestyle habits, gender differences, and their association with sleep and mental health among Syrian medical residents.BMC psychiatry · 2026Article
- Longitudinal effects of bushfire harm on adolescent mental health.The Australian and New Zealand journal of psychiatry · 2026Article
- Gender Differential Morbidity in Quality of Life and Coping Among People Diagnosed with Depression and Anxiety Disorders.Healthcare (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
purposeConsiderable empirical evidence indicates that stressful life experiences may have a negative impact on mental health. However, it is unclear how multiple adverse experiences may intersect to influence symptoms of depression and anxiety. Using a syndemics approach to identify potential synergistic effects between major stressors, we aimed to quantify the roles of multiple recent adverse life experiences on depression and anxiety symptoms.
methodsA population-representative sample of 1090 Australian adults (53% women, M
resultsThe most common adverse life experiences in the past year were financial problems (64%), loneliness (63%), or a major health problem (51%). In multivariate logistic regression analyses, financial problems, personal health problems, health problems in a close contact, relationship problems and loneliness were significantly associated with both depression and anxiety symptoms (p < 0.05). There was just one synergistic interaction and one buffering interaction of combined adversities on anxiety, and no synergistic interactions of adverse experiences on depression. The perceived impact of combined adversities was associated with both depression (b = 0.59, p < 0.001) and anxiety (b = 0.48, p < 0.001).
conclusionAdversity was strongly associated with depression and anxiety. Inconsistent with a syndemics framework, there were very few synergistic relationships between different types of adversities, suggesting that different adverse experiences may independently influence mental health. The findings indicate important opportunities for early intervention to prevent depression and anxiety during difficult times.
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