ReviewPhysiological reviews2024
Neurobiology and systems biology of stress resilience.
Review in Physiological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Neural correlates of acute task-related stress in humans: a systematic review and coordinate-based ALE meta-analysis.Brain imaging and behavior · 2026Pooled it
- Current evidence and future directions for social and societal resilience factors in response to societal challenges and crises: an overview of systematic reviews and expert rating.BMC public health · 2025Pooled it
- Efficacy of a self-guided online resilience intervention for improving mental health among university students: A randomized controlled trial.Scientific reports · 2026Trial
- Exploring stressor exposure and mental health symptom patterns among forcibly displaced people: A latent profile analysis.Journal of traumatic stress · 2026Article
- Resilience beyond diagnosis: prospective neural correlates of better-than-expected outcomes in depression.Molecular psychiatry · 2026Article
- Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice.Molecular psychiatry · 2026Article
- A ventral striatal learning signal reflecting individual differences in the success of fear extinction.Molecular psychiatry · 2026Article
- Bouncing back from stress: objective markers of expressive flexibility and resilience in emergency healthcare workers using computer vision.NPP - digital psychiatry and neuroscience · 2026Article
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Neuroticism, perceived stress, psychological resilience, and pre-dive state anxiety in professional divers: a cross-sectional study.BMC psychology · 2026Article
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.Translational psychiatry · 2026Article
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.Translational psychiatry · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Bayesian Mixed Models Approach to Exploring Resilience: Impact of Stress on Subjective Health and Affects Over Time During the COVID-19 Pandemic.International journal of methods in psychiatric research · 2026Article
- NLRP3-Mediated Neuroinflammation Participates in Resilience to PSD in C57BL/6 Mice.Biomedicines · 2026Article
- Disrupted rich club organization in structural brain networks is related to childhood maltreatment in major depressive disorder.Frontiers in psychiatry · 2026Article
- Bridging reward and resilience: the endocannabinoid system as a unifying mechanism in exercise-induced protection against major depressive disorder.Frontiers in psychiatry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts to unravel the factors and mechanisms that make resilience possible and to harness its insights for the development of preventative interventions in individuals at risk for acquiring stress-related dysfunctions. Biological resilience research has been lagging behind the psychological and social sciences but has seen a massive surge in recent years. At the same time, progress in this field has been hampered by methodological challenges related to finding suitable operationalizations and study designs, replicating findings, and modeling resilience in animals. We embed a review of behavioral, neuroimaging, neurobiological, and systems biological findings in adults in a critical methods discussion. We find preliminary evidence that hippocampus-based pattern separation and prefrontal-based cognitive control functions protect against the development of pathological fears in the aftermath of singular, event-type stressors [as found in fear-related disorders, including simpler forms of posttraumatic stress disorder (PTSD)] by facilitating the perception of safety. Reward system-based pursuit and savoring of positive reinforcers appear to protect against the development of more generalized dysfunctions of the anxious-depressive spectrum resulting from more severe or longer-lasting stressors (as in depression, generalized or comorbid anxiety, or severe PTSD). Links between preserved functioning of these neural systems under stress and neuroplasticity, immunoregulation, gut microbiome composition, and integrity of the gut barrier and the blood-brain barrier are beginning to emerge. On this basis, avenues for biological interventions are pointed out.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.