ArticleJournal of veterinary internal medicine
Prognosis in meningoencephalitis of unknown origin in dogs: Risk factors associated with survival, clinical relapse, and long-term disability.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cervical Pain in Non-Chondrodystrophic Dogs: Associations with Clinical Onset, Neurological Group and Disease Category.Animals : an open access journal from MDPI · 2026Article
- Detection of neural autoantibodies in dogs with non-infectious inflammatory central nervous system disorders.Journal of veterinary internal medicine · 2026Article
- Clinical presentation, prognostic factors, and outcomes of meningoencephalitis of unknown origin in older dogs.Journal of veterinary internal medicine · 2026Article
- NMR metabolomic profiling of cerebrospinal fluid from dogs with meningoencephalitis of unknown origin demonstrates metabolic similarities to multiple sclerosis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Evaluation of 600 mg/m2 cytarabine arabinoside as treatment for meningoencephalomyelitis of unknown origin in 43 dogs.Journal of veterinary internal medicine · 2026Article
- Cerebrospinal fluid markers and magnetic resonance imaging lesion volume predicting relapse in canine meningoencephalitis of unknown origin.Frontiers in veterinary science · 2026Article
- Prognostic value of the hemoglobin, albumin, lymphocyte, and platelet score for short-term mortality in dogs with meningoencephalitis of unknown etiology.Frontiers in veterinary science · 2026Article
- Responsiveness of the neurodisability scale for meningoencephalitis of unknown origin in dogs.The Journal of small animal practice · 2025Article
- Usefulness of neurological assessment scales in prognosis of meningoencephalitis of unknown origin in Yorkshire Terriers.BMC veterinary research · 2025Article
- The role of regulatory T cells in central nervous system diseases in dogs: fighting with a double-edged sword toward translational discoveries.American journal of translational research · 2025Review
- Meningoencephalitis of unknown origin in dogs under veterinary referral care in England (2017-2021): a multicenter case control study.Frontiers in veterinary science · 2025Article
- Magnetic resonance imaging prognostic factors for survival and relapse in dogs with meningoencephalitis of unknown origin.Frontiers in veterinary science · 2024Article
- Of potential new treatment targets and polythetic approach in meningoencephalitis of unknown origin: a review.Frontiers in veterinary science · 2024Review
- Brain Atrophy in Dogs With Meningoencephalitis of Unknown Origin.Journal of veterinary internal medicineArticle
- Evolution of Brain Magnetic Resonance Imaging Lesions in Dogs Treated for Meningoencephalomyelitis of Unknown Origin Between Initial Diagnosis and Relapse.Journal of veterinary internal medicineArticle
- Prognosis in meningoencephalitis of unknown origin in dogs: Risk factors associated with survival, clinical relapse, and long-term disability.Journal of veterinary internal medicineArticle
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4 authors.
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Abstract
backgroundMeningoencephalitis of unknown origin (MUO) comprises a group of noninfectious inflammatory diseases affecting the central nervous system of dogs. Previous studies have reported individual risk factors for survival but prognostication for MUO remains challenging.
objectivesIdentify clinical prognostic variables in dogs with MUO. ANIMALS: A retrospective study of 447 dogs presented to 2 UK referral hospitals and diagnosed with MUO.
methodsMedical records of dogs diagnosed with MUO were retrospectively reviewed. Multivariable logistic regression was used for the identification of risk factors for survival and Cox proportional hazards analysis for the identification of risk factors for clinical relapse.
resultsEighty-two percent (366/447) of dogs with presumptive MUO survived to discharge and 63.5% (284/447) were alive at 6 months; 36% of the latter (103/284) had persistent neurological deficits. Breed (pugs; P = .03), epileptic seizures (P < .001), paresis (P < .001), and higher neurodisability scale (NDS) score (P < .001) at presentation were negatively associated with survival to 6 months. Dogs with persistent deficits had higher NDS scores on presentation (P = .001). Median follow-up time was 11 months (interquartile range [IQR], 1-24) and 50.6% (160/316) relapsed during treatment (median time to relapse, 7 months; IQR, 2-15). Incomplete resolution of the clinical signs during the 6 months after diagnosis (P < .001), higher NDS score (P < .001), and longer duration of the clinical signs (P < .001) were associated with relapse. CONCLUSIONS AND CLINICAL IMPORTANCE: Knowledge of risk factors associated with survival, incomplete recovery and clinical relapse in MUO can help guide monitoring and treatment and improve owner communications regarding prognosis for this debilitating disease.
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