ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Longer residence in disadvantaged neighborhoods predicts both a syndrome of despair and deaths of despair: Complementary evidence from nationwide register and birth-cohort studies.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- Neighborhood socioeconomic deprivation is associated with worse cognitive performance and in vivo amyloid accumulation.NPJ dementia · 2026Article
- Neurocognitive disorders, depression, and associated factors in younger and older adults from an urban-marginalized area of Peru.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Grey literature scoping review: a synthesis of the application of participatory methodologies in underrepresented groups at an elevated risk of dementia.BMC medical research methodology · 2025Article
- More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.Brain communications · 2025Article
- Higher socioeconomic deprivation in areas predicts cognitive decline in New Zealanders without cognitive impairment.Scientific reports · 2024Article
- Dementia, dementia's risk factors and premorbid brain structure are concentrated in disadvantaged areas: National register and birth-cohort geographic analyses.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Applications and implicit assumptions in dementia risk scores: A scoping review of the LIBRA score.Journal of Alzheimer's disease reportsReview
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Authors and funding
16 authors.
Funding
Abstract
introductionDementia risk may be elevated in socioeconomically disadvantaged neighborhoods. Reasons for this remain unclear, and this elevation has yet to be shown at a national population level.
methodsWe tested whether dementia was more prevalent in disadvantaged neighborhoods across the New Zealand population (N = 1.41 million analytic sample) over a 20-year observation. We then tested whether premorbid dementia risk factors and MRI-measured brain-structure antecedents were more prevalent among midlife residents of disadvantaged neighborhoods in a population-representative NZ-birth-cohort (N = 938 analytic sample).
resultsPeople residing in disadvantaged neighborhoods were at greater risk of dementia (HR per-quintile-disadvantage-increase = 1.09, 95% confidence interval [CI]:1.08-1.10) and, decades before clinical endpoints typically emerge, evidenced elevated dementia-risk scores (CAIDE, LIBRA, Lancet, ANU-ADRI, DunedinARB; β's 0.31-0.39) and displayed dementia-associated brain structural deficits and cognitive difficulties/decline. DISCUSSION: Disadvantaged neighborhoods have more residents with dementia, and decades before dementia is diagnosed, residents have more dementia-risk factors and brain-structure antecedents. Whether or not neighborhoods causally influence risk, they may offer scalable opportunities for primary dementia prevention.
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