Evidence map›Paper›PMID 38482671›Full record

ReviewPathologica2024

Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature.

Alessandro Marando, Moreno Zagni, Mariachiara Negrelli, Emanuele Valtorta, Calogero Lauricella, Valentina Motta, Silvio Veronese, Giulio Cerea, Laura Giuseppina Giannetta, Gabriele Ciarlo and 4 more

Abstract readReview
In one paragraph

Review in Pathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alessandro MarandoDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Moreno ZagniPostgraduate School of Pathology, University of Milan, Milan, Italy.
Mariachiara NegrelliPostgraduate School of Pathology, University of Milan, Milan, Italy.
Emanuele ValtortaDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Calogero LauricellaDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Valentina MottaDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Silvio VeroneseDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Giulio CereaNiguarda Cancer Center, ASST Grande Ospedale Niguarda, Milan, Italy.
Laura Giuseppina GiannettaNiguarda Cancer Center, ASST Grande Ospedale Niguarda, Milan, Italy.
Gabriele CiarloNiguarda Cancer Center, ASST Grande Ospedale Niguarda, Milan, Italy.
Diego SignorelliNiguarda Cancer Center, ASST Grande Ospedale Niguarda, Milan, Italy.
Elio Gregory PizzutiloNiguarda Cancer Center, ASST Grande Ospedale Niguarda, Milan, Italy.
Emanuela BonoldiDepartment of Pathology, ASST Grande Ospedale Niguarda, Milan, Italy.
Giuseppe PelosiPostgraduate School of Pathology, University of Milan, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.

Indexed as

AdenocarcinomaCarcinoma, Non-Small-Cell LungLung NeoplasmsBiomarkers, TumorHumansLungPrognosisBiomarkers, Tumorbiphenotypic lung cancerlung adenocarcinomalung adenosquamous carcinomalung cancer immunohistochemistrylung squamous cell carcinoma

Identifiers

PMID38482671
PMCPMC10938280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.