ArticleThe Journal of clinical endocrinology and metabolism2025
Triglyceride-glucose Index and Mortality in a Large Regional-based Italian Database (URRAH Project).
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Triglyceride-Glucose Index and Mortality Risk in the General Population: A Systematic Review and Meta-analysis of Prospective Studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Pooled it
- Triglyceride-glucose index and the outcome of peritoneal dialysis patients: analysis of two cohorts.BMC nephrology · 2026Article
- The role of triglyceride-glucose (TyG) index in predicting mortality risk in critically ill patients with sepsis: a machine learning model in a cohort study.BMC medical informatics and decision making · 2026Article
- Assessment of Triglyceride/High-Density Lipoprotein Cholesterol Ratio and Triglyceride-Glucose Index Threshold in Patients with Chronic Kidney Disease: Evaluation of Clinical Features and Outcomes.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- The Triglyceride-Glucose Index: A Novel Marker for Clinical Atherosclerotic Cardiovascular Disease Risk Stratification.Annals of African medicine · 2026Review
- Triglyceride-glucose index, HOmeostatic Model Assessment index, and new-onset hypertension in middle-aged men.Journal of hypertension · 2026Article
- Propensity score analysis of triglyceride-glucose index in newly diagnosed patients with essential hypertension as a predictor of microalbuminuria.Frontiers in endocrinology · 2026Observational
- Serum Uric Acid in the PAMELA Study: Main Findings and Association with the Atherogenic Index of Plasma.Metabolites · 2025Review
- Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project.American journal of preventive cardiology · 2025Article
- Triglyceride-Glucose Index and New-Onset Type 2 Diabetes Mellitus in Middle-Aged Men.Metabolites · 2025Article
- Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- The association between the triglyceride-glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography.Cardiovascular diabetology · 2025Article
- Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population.Cardiovascular diabetology · 2025Article
- Atherosclerosis and the Bidirectional Relationship Between Cancer and Cardiovascular Disease: From Bench to Bedside, Part 2 Management.International journal of molecular sciences · 2025Review
- An Increasing Triglyceride-Glucose Index Is Associated with a Pro-Inflammatory and Pro-Oxidant Phenotype.Journal of clinical medicine · 2024Article
- Correlation between triglyceride glucose-body mass index and hypertension risk: evidence from a cross-sectional study with 60,283 adults in eastern China.BMC cardiovascular disorders · 2024Article
- Non-Interventional Weight Changes Are Associated with Alterations in Serum Uric Acid Levels.Journal of clinical medicine · 2024Article
- Value of the triglyceride-glucose index and related parameters in heart failure patients.Frontiers in cardiovascular medicine · 2024Review
- Association between triglyceride glucose index and hyperuricemia: a new evidence from China and the United States.Frontiers in endocrinology · 2024Article
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Authors and funding
45 authors.
Funding
Abstract
purposeRecently, a novel index [the triglyceride-glucose (TyG) index]) was considered a surrogate marker of insulin resistance (IR); in addition, it was estimated to be a better expression of IR than widely used tools. Few and heterogeneous data are available on the relationship between this index and mortality risk in non-Asian populations. Therefore, we estimated the predictive role of baseline TyG on the incidence of all-cause and cardiovascular (CV) mortality in a large sample of the general population. Moreover, in consideration of the well-recognized role of serum uric acid (SUA) on CV risk and the close correlation between SUA and IR, we also evaluated the combined effect of TyG and SUA on mortality risk.
methodsThe analysis included 16 649 participants from the URRAH cohort. The risk of all-cause and CV mortality was evaluated by the Kaplan-Meier estimator and Cox multivariate analysis.
resultsDuring a median follow-up of 144 months, 2569 deaths occurred. We stratified the sample by the optimal cut-off point for all-cause (4.62) and CV mortality (4.53). In the multivariate Cox regression analyses, participants with TyG above cut-off had a significantly higher risk of all-cause and CV mortality than those with TyG below the cut-off. Moreover, the simultaneous presence of high levels of TyG and SUA was associated with a higher mortality risk than none or only 1 of the 2 factors.
conclusionThe results of this study indicate that these TyG (a low-cost and simple, noninvasive marker) thresholds are predictive of an increased risk of mortality in a large and homogeneous general population. In addition, these results show a synergic effect of TyG and SUA on the risk of mortality.
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