Evidence map›Paper›PMID 38482570›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease.

John M Giacona, Areeb Afridi, Ursa Bezan Petric, Talon Johnson, Johanne Pastor, Jimin Ren, Lona Sandon, Craig Malloy, Ambarish Pandey, Amil Shah and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Skeletal MuscleDiagnostics (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

John M GiaconaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-0334-9876
Areeb AfridiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Ursa Bezan PetricDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-3375-0599
Talon JohnsonAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Johanne PastorCharles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Jimin RenAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Lona SandonDepartment of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Craig MalloyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Ambarish PandeyDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Amil ShahDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Jarett D BerryDepartment of Internal Medicine, University of Texas Health Science Center at Tyler, Tyler, Texas, United States.ORCID 0000-0002-5004-8155
Orson W MoeDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0001-9176-3414
Wanpen VongpatanasinDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0002-7531-9388
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · USThe University of Texas Health Science Center at Tyler · US

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral AdiposityR01HL159994 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Jarett D Berry, WANPEN VONGPATANASIN · 2022 to 2026
$4.0M
HHS | National Institutes of Health (NIH) HL159994NHLBI NIH HHS R01 HL159994NIDDK NIH HHS P30 DK127984
6 · The paper itself

Abstract

Highly bioavailable inorganic phosphate (Pi) is present in large quantities in the typical Western diet and represents a large fraction of total phosphate intake. Dietary Pi excess induces exercise intolerance and skeletal muscle mitochondrial dysfunction in normal mice. However, the relevance of this to humans remains unknown. The study was conducted on 13 individuals without a history of cardiopulmonary disease (46% female, 15% Black participants) enrolled in the pilot-phase of the Dallas Heart and Mind Study. Total dietary phosphate was estimated from 24-h dietary recall (ASA24). Muscle ATP synthesis was measured at rest, and phosphocreatinine (PCr) dynamics was measured during plantar flexion exercise using 7-T

Indexed as

Cardiovascular DiseasesPhosphatesAdenosine TriphosphateAdultAnimalsEnergy MetabolismFemaleHumansMaleMiceMuscle, SkeletalPhosphocreatineAdenosine TriphosphatePhosphatesPhosphocreatinedietary phosphateexercise intolerancemitochondrial function

Identifiers

PMID38482570
PMCPMC11575913
OpenAlexW4392812802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.