Evidence map›Paper›PMID 38482552›Full record

ArticleJournal of neurochemistry2024

Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa.

Wyn Firth, Josephine L Robb, Daisy Stewart, Katherine R Pye, Rosemary Bamford, Asami Oguro-Ando, Craig Beall, Kate L J Ellacott

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wyn FirthDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0001-6531-2580
Josephine L RobbDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-6955-7355
Daisy StewartDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0009-0000-4155-1747
Katherine R PyeDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-0691-6007
Rosemary BamfordDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-2107-4637
Asami Oguro-AndoDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0003-4029-3250
Craig BeallDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0002-4263-0866
Kate L J EllacottDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0001-5261-7465
University of Exeter · GB

Funding

British Society for NeuroendocrinologyMedical Research Council MR/R014345/1Research England
6 · The paper itself

Abstract

The mitochondrial translocator protein 18 kDa (TSPO) has been linked to functions from steroidogenesis to regulation of cellular metabolism and is an attractive therapeutic target for chronic CNS inflammation. Studies in Leydig cells and microglia indicate that TSPO function may vary between cells depending on their specialized roles. Astrocytes are critical for providing trophic and metabolic support in the brain. Recent work has highlighted that TSPO expression increases in astrocytes under inflamed conditions and may drive astrocyte reactivity. Relatively little is known about the role TSPO plays in regulating astrocyte metabolism and whether this protein is involved in immunometabolic processes in these cells. Using TSPO-deficient (TSPO

Indexed as

AstrocytesMice, KnockoutReceptors, GABAAnimalsCell Line, TumorCells, CulturedEnergy MetabolismHumansMiceMice, Inbred C57BLMitochondriaBzrp protein, mouseReceptors, GABATSPO protein, humanastrocytecytokine releasefatty acid oxidationinflammationmetabolismTSPO

Identifiers

PMID38482552
OpenAlexW4392816959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.