Evidence map›Paper›PMID 38482502›Full record

ArticleiScience2024

TET2 regulation of alcoholic fatty liver via

Qinjin Li, Yanyan Pan, Jing Zhang, Boxu Hu, Dan Qin, Shenghui Liu, Ning Chen, Lisheng Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qinjin LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Yanyan PanCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Jing ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Boxu HuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Dan QinCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Shenghui LiuCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ning ChenCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Lisheng ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Huazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modifications have emerged as key regulators of metabolism-related complex diseases including the alcoholic fatty liver disease (AFLD) prevalent chronic liver disorder with significant economic implications. Building upon previous research that emphasizes ten-eleven translocation (TET) proteins' involvement in adipocyte insulin sensitization and fatty acid oxidation, we explored the role of TET2 protein in AFLD pathogenesis which catalyzes 5-methylcytosine into 5-hydroxymethylcytosine in DNA/RNA. Our findings revealed that TET2 deficiency exacerbates AFLD progression. And TET2 influenced the expression and activity of sterol regulatory element binding protein 1 (SREBP1), a key regulator of hepatic lipid synthesis, by modulating

Indexed as

Classification Description: Molecular biologyEpigeneticsMolecular mechanism of gene regulation

Identifiers

PMID38482502
PMCPMC10933471
OpenAlexW4391969730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.