Evidence map›Paper›PMID 38481545›Full record

ArticleJournal of traditional and complementary medicine2024

Antispasmodic, cardioprotective and blood-pressure lowering properties of

Adriana Milena Bonilla Bonilla, Tatiana C Gavilánez Buñay, Matías Bayley, Germán A Colareda, Soledad I Matera, María Luján Flores, Osvaldo León Córdoba, Julián J Prieto, María Esperanza Ruiz, Alicia E Consolini and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Adriana Milena Bonilla BonillaCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Tatiana C Gavilánez BuñayCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Matías BayleyCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Germán A ColaredaCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Soledad I MateraCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
María Luján FloresCátedra de Farmacognosia, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Comodoro Rivadavia, Chubut, Argentina.
Osvaldo León CórdobaCátedra de Química Biológica II, Grupo de Investigación en Química, Bioactividad y Metabolismo de Recursos Naturales Patagónicos, AAI, CRIDECIT, Facultad de Ciencias Naturales y Ciencias de la Salud, Universidad Nacional de la Patagonia San Juan Bosco, Comodoro Rivadavia, Chubut, Argentina.
Julián J PrietoCátedra de Control de Calidad. Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
María Esperanza RuizCátedra de Control de Calidad. Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Alicia E ConsoliniCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
María Inés RagoneCátedra de Farmacología, Grupo de Farmacología Experimental y Energética Cardíaca (GFEYEC) and Maestría en Plantas Medicinales, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Universidad Nacional de La Plata · ARNational University of Patagonia San Juan Bosco · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aim: To evaluate the cardiovascular and intestinal pharmacological effects of Experimental procedure: The chromatographic profile of GphT was done. Its Results: Fifteen flavonoids were identified in GphT by HPLC-UV, including diosmin. GphT induced a non-competitive inhibition in both carbachol and calcium CRCs on rat small intestine. The first was not affected by indomethacin. Moreover, GphT, unlike diosmin, relaxed the contracture produced by a high-potassium solution in a dose-dependently way. Neither propranolol nor l-NAME changed it. GphT did not show diuretic activity but induced hypotension insensitive to l-NAME. While GphT perfusion of isolated hearts increased injury consequent to I/R, oral administration was cardioprotective and reversed by l-NAME. However, diosmin did not improve the post-ischemic recovery. Conclusions: This study supports the use of

Indexed as

AntispasmodicBlood pressureCardioprotectionGomphrena perennisNitric oxide

Identifiers

PMID38481545
PMCPMC10927383
OpenAlexW4388036831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.