ArticleKidney international reports2024
Prospective Study of Ultrasound Markers of Organ Congestion in Critically Ill Patients With Acute Kidney Injury.
Article in Kidney international reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- A Pilot Randomized Controlled Trial of Ultrasound Evaluation of Fluid Tolerance for Acute Kidney Injury: USE-the-FORCE-for-AKI Trial.Clinical journal of the American Society of Nephrology : CJASN · 2026Trial
- Portal Vein Doppler Parameters as Indicators of Volume Status in Hemodialysis Patients Using Wireless Ultrasound.Cureus · 2026Article
- The expanding role of ultrasound in acute kidney injury: from B-mode to microcirculation.Clinical kidney journal · 2026Review
- Rethinking Congestion in Heart Failure from Volume Overload to Venous Pressure and Organ Disfunction with VExUS.Medicina (Kaunas, Lithuania) · 2026Review
- Assessment of hydrosodic balance by impedancemetry in intensive care: a monocentric prospective study, the EBaHIR study.Annals of medicine and surgery (2012) · 2026Article
- Association between VExUS score and worsening renal function during diuretic therapy in the ICU.Intensive care medicine experimental · 2026Article
- The fluid paradox: dissociation between clinical and ultrasound parameters of fluid overload - results of the INCIVEX exploratory study.Anaesthesiology intensive therapy · 2026Observational
- A comprehensive review of venous excess ultrasound (VExUS) score: evidence from original research.Internal and emergency medicine · 2026Review
- Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure.Critical care explorations · 2026Observational
- Ultrasound of the inferior vena cava for fluid therapy decisions: Strengths, limitations, and an integrated approach.The Journal of international medical research · 2026Review
- Extended venous excess ultrasound: A promising addition to point-of-care ultrasound-based venous congestion assessment.World journal of cardiology · 2026Review
- Biomarker-driven risk stratification and early intervention in acute kidney injury: a comprehensive review from early warning to clinical response.Frontiers in medicine · 2026Review
- Venous congestion in critical care: combining VExUS, lung ultrasound, and echocardiography.Annals of intensive care · 2026Article
- Renal microcirculation in acute kidney injury: bridging haemodynamics, inflammation and repair.Annals of intensive care · 2026Review
- Venous excess and lung ultrasound during continuous renal replacement therapy in critically ill patients (VExLUS-RRT): a prospective observational study.Annals of intensive care · 2026Article
- Ultrasound indicators of organ venous congestion: a narrative review.Annals of intensive care · 2025Review
- Diuresis increase after positive end-expiratory pressure weaning during acute respiratory distress syndrome.Scientific reports · 2025Article
- Intrarenal venous flow patterns and their association with successful fluid removal in critically ill patients: a prospective observational exploratory study.The ultrasound journal · 2025Article
- The VTI-VeXUS Index in Septic Shock: An Exploratory Proof-of-Concept Observational Study of a Novel Hemodynamic Parameter.Journal of clinical medicine · 2025Article
- Point-of-Care Ultrasound Use in Hemodynamic Assessment.Biomedicines · 2025Review
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Organ congestion may be a mediator of adverse outcomes in critically ill patients with severe acute kidney injury (AKI). The presence of abnormal venous Doppler waveforms could identify patients with clinically significant organ congestion who may benefit from a decongestive strategy. Methods: This prospective multicenter cohort study enrolled patients with severe AKI defined as Kidney Disease: Improving Global Outcomes stage 2 or higher. Patients were not eligible if they received renal replacement therapy (RRT) for more than 72 hours at the time of screening. Participants underwent serial Doppler ultrasound examinations of the portal, hepatic and intrarenal veins during the week following enrolment. We calculated the venous excess ultrasound (VExUS) score based on these data. The primary outcome studied was major adverse kidney events at 30 days (MAKE30) defined as death, RRT dependence, or a persistent decrease in kidney function. Results: A total of 125 patients were included for whom 291 ultrasound assessments were performed. Severely abnormal venous waveforms were documented in 14.4% of portal vein assessments, 6.5% of intrarenal venous assessments, and 14.4% of hepatic vein assessments. The individual ultrasound markers were not associated with MAKE30. The VExUS score (grade 0-1: reference; grade 2: adjusted hazard ratio [aHR]: 4.03, confidence interval [CI]: 1.81-8.99; grade 3: aHR: 2.70, CI: 1.10-6.65; Conclusion: Although not significantly associated with MAKE30, venous Doppler abnormalities suggestive of venous congestion were associated with higher mortality in critically ill patients with severe AKI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.