Evidence map›Paper›PMID 38481440›Full record

ArticleFrontiers in endocrinology2024

Case report: Management of pediatric gigantism caused by the TADopathy, X-linked acrogigantism.

Manuela Caruso, Diego Mazzatenta, Sofia Asioli, Giuseppe Costanza, Giampaolo Trivellin, Martin Franke, Dayana Abboud, Julien Hanson, Véronique Raverot, Patrick Pétrossians and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Genetics of familial acromegaly and pituitary gigantism.The Journal of clinical endocrinology and metabolism · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Manuela CarusoDepartment of Pediatrics, Azienda Policlinico Università di Catania, Catania, Italy.
Diego MazzatentaDepartment of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Sofia AsioliDepartment of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Giuseppe CostanzaDepartment of Pediatrics, Azienda Policlinico Università di Catania, Catania, Italy.
Giampaolo TrivellinDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Martin FrankeAndalusian Center for Developmental Biology (CABD), Junta de Andalucía- Universidad Pablo de Olavide (UPO) - Consejo Superior de Investigaciones Cientificas (CSIC), Sevilla, Spain.
Dayana AbboudCenter for Interdisciplinary Research on Medicines (CIRM) - Laboratory of Medicinal Chemistry, and Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, Liège, Belgium.
Julien HansonCenter for Interdisciplinary Research on Medicines (CIRM) - Laboratory of Medicinal Chemistry, and Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, Liège, Belgium.
Véronique RaverotLaboratoire d'hormonologie Centre de Biologie et Pathologie Est (CBPE)-Groupement Hospitalier Est, Hospices civils de Lyon, Bron, France.
Patrick PétrossiansDepartment of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Albert BeckersDepartment of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Marco CappaResearch Unit, Innovative Therapies for Endocrinopathies, Scientific Directorate, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Adrian F DalyDepartment of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
University of Liège · BEPoliclinico Universitario di Catania · ITCentre Hospitalier Universitaire de Liège · BECentro Andaluz de Biología del Desarrollo · ESHospices Civils de Lyon · FRHumanitas University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto delle Scienze Neurologiche di Bologna · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplication on chromosome Xq26.3 that leads to the misexpression of the gene

Indexed as

AcromegalyGenetic Diseases, X-LinkedGigantismHuman Growth HormonePituitary NeoplasmsAdultChildChild, PreschoolFemaleGrowth HormoneHumansGrowth HormoneHuman Growth HormonegigantismGPR101pituitary tumorsomatostatin analogtopologically associating domain (TAD)

Identifiers

PMID38481440
PMCPMC10932951
OpenAlexW4392236094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.