Evidence map›Paper›PMID 38481355›Full record

ArticleClinical and experimental dental research2024

Downregulation of salivary miR-3928 as a potential biomarker in patients with oral squamous cell carcinoma and oral lichen planus.

Alieh Farshbaf, Farnaz Mohajertehran, Seyed Hamid Aghaee-Bakhtiari, Hossein Ayatollahi, Katayoun Douzandeh, Atessa Pakfetrat, Nooshin Mohtasham

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Article in Clinical and experimental dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alieh FarshbafDental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Farnaz MohajertehranOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Hamid Aghaee-BakhtiariDepartment of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein AyatollahiHematology Department, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Katayoun DouzandehStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Atessa PakfetratOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nooshin MohtashamOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-1262-4668

Funding

Mashhad University of Medical Sciences
6 · The paper itself

Abstract

objectivesRecent studies highlighted the role of miR expressed in saliva as reliable diagnostic and prognostic tools in the long-term monitoring of cancer processes such as oral squamous carcinoma (OSCC). Based on a few previous studies, it seems the miR-3928 can be considered a master regulator in carcinogenesis, and it can be therapeutically exploited. This is the first study that compared oral potentially malignant disorder (OLP) and malignant (OSCC) lesions for miR-3928 expression. MATERIALS AND

methodsIn this cross-sectional study, saliva samples from 30 healthy control individuals, 30 patients with erosive/atrophic oral lichen planus, and 31 patients with OSCC were collected. The evaluation of miR-3928 expression by q-PCR and its correlation with clinicopathological indices were analyzed by Shapiro-Wilk, Kruskal-Wallis, Pearson's χ

resultsBased on nonparametric Kruskal-Wallis test results, there was a statistically significant difference between the ages of three study groups (p < .05). This test demonstrated a statistically significant difference between the average of miR-3928 expression in three study groups (p < .05). The result of the χ

conclusionsThe salivary miR-3928 can play a tumor suppressive role in the pathobiology of OSCC, and it is significantly downregulated in patients. According to the potential tumor suppressive role of miR-3928 in the OSCC process, we can consider this microRNA as a biomarker for future early diagnosis, screening, and potential target therapy.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsLichen Planus, OralMicroRNAsMouth NeoplasmsBiomarkersCross-Sectional StudiesDown-RegulationHumansSquamous Cell Carcinoma of Head and NeckBiomarkersMicroRNAshead and neck squamous cell carcinomamiR-3928oral canceroral squamous cell carcinoma

Identifiers

PMID38481355
PMCPMC10938069

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