ArticleRadiation oncology (London, England)2024
Apparent diffusion coefficient values predict response to brachytherapy in bulky cervical cancer.
Article in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Intravoxel incoherent motion imaging with improved image quality by deep learning reconstruction for prediction of lymph-vascular space invasion in patients with cervical cancer.Abdominal radiology (New York) · 2026Article
- Prognostic factors of locally advanced cervical cancer after concurrent chemoradiotherapy: a retrospective study.BMC cancer · 2025Article
- Intra-voxel incoherent motion biomarker repeatability in healthy volunteers and sensitivity to chemoradiotherapy-induced changes in patients with uterine cervical cancer.Frontiers in oncology · 2025Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
backgroundDiffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radiation therapy (EBRT) DWI and prior to brachytherapy (BT) to predict for complete metabolic response (CMR) in bulky cervical cancer.
methodsClinical and DWI (b value = 500 s/mm
resultsAmong 45 patients, twenty-eight (62%) achieved a CMR. On univariate analysis for CMR, only 90th percentile ADC value was significant (p = 0.029) while other imaging and clinical factors were not. Borderline significant factors were HR-CTV size (p = 0.054) and number of chemotherapy cycles (p = 0.078). On multivariate analysis 90th percentile ADC (p < 0.0001) and HR-CTV size (p < 0.003) were highly significant. Patients with 90th percentile ADC values above 2.10 × 10
conclusionsClinical DWI may serve to risk-stratify patients undergoing interstitial BT for bulky cervical cancer.
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