Evidence map›Paper›PMID 38481205›Full record

ArticleBMC ophthalmology2024

Vogt-Koyanagi-Harada disease developed during chemotherapy for Hodgkin lymphoma: a case report.

Mutsumi Koyama, Euido Nishijima, Takaya Honda, Chizuru Gonmori-Ohta, Takeaki Sasamoto, Katsuyuki Tanaka, Akira Watanabe, Tadashi Nakano, Masaharu Akiyama

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mutsumi KoyamaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
Euido NishijimaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
Takaya HondaDepartment of Pediatrics, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
Chizuru Gonmori-OhtaDepartment of Pediatrics, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
Takeaki SasamotoDepartment of Pediatrics, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
Katsuyuki TanakaDepartment of Pediatrics, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan.
Akira WatanabeDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8561, Tokyo, Japan.
Masaharu AkiyamaDepartment of Pediatrics, The Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-8461, Tokyo, Japan. makiyama@jikei.ac.jp.
Jikei University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOcular manifestations are known for non-Hodgkin lymphoma, but are rare for Hodgkin lymphoma. We report a case of Vogt-Koyanagi-Harada (VKH) disease presenting as serous retinal detachment and uveitis in both eyes in a child undergoing chemotherapy for Hodgkin lymphoma. CASE PRESENTATION: The patient was a 7-year-old boy with stage IIB Hodgkin lymphoma (nodular lymphocyte predominant type) who was undergoing chemotherapy, including 2 cycles of the OEPA regimen and 1 cycle of the COPDAC regimen. Two days after the end of the COPDAC regimen, the patient complained of headache and of blurred and decreased vision in both eyes. On the basis of optic symptoms, such as uveitis and serous retinal detachment in both eyes, increased cell counts in cerebrospinal fluid, and positivity for human leukocyte antigen (HLA)-DR4 in peripheral blood cells, incomplete VKH disease was diagnosed. Intravenous treatment with high-dose prednisolone (60mg/m

conclusionThe onset of VKH disease occurred during chemotherapy for Hodgkin lymphoma. The patient was HLA-DR4-positive and might have had a predisposition to develop autoimmune diseases, including VKH disease. However, the anticancer drugs administered to this patient have not been reported to cause uveitis. Whether Hodgkin lymphoma triggered the development of VKH remains unclear. Early diagnosis of VKH disease and prompt treatment with high-dose prednisone enabled the patient to maintain good visual function despite chemotherapy for Hodgkin lymphoma.

Indexed as

Hodgkin DiseaseRetinal DetachmentUveomeningoencephalitic SyndromeChildGlucocorticoidsHumansMalePrednisoloneGlucocorticoidsPrednisoloneChildHodgkin lymphomaUveitisVogt-Koyanagi-Harada disease

Identifiers

PMID38481205
PMCPMC10935796
OpenAlexW4392752157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.