Evidence map›Paper›PMID 38481058›Full record

ArticleAging cell2024

The aged microenvironment impairs BCL6 and CD40L induction in CD4

Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07346820 (VDJ-recombination of the B-cell Receptor Following Hematopoietic Stem Cell Transplantation, an Observational Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07346820 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

VDJ-recombination of the B-cell Receptor Following Hematopoietic Stem Cell Transplantation, an Observational Study

TypeobservationalSponsorUmeå UniversityRan2026 to 2036Enrolled65ConditionsStem Cell Transplantation, Hematopoietic, V(D)J Recombination, Receptors, Antigen, B-Cel
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jacob S FisherDepartment of Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
Irene Adán-BarrientosImmunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Naveen R KumarDepartment of Immunology, Mayo Clinic, Scottsdale, Arizona, USA.
Jessica N LancasterDepartment of Immunology, Mayo Clinic, Scottsdale, Arizona, USA.ORCID 0000-0003-0398-9988
Mayo Clinic in Arizona · USSpanish National Centre for Cardiovascular Research · ES

Funding

The role of lymph node structural organization in naïve T cell decline with ageR01AG080037 · NIA · MAYO CLINIC ARIZONA · PI Jessica N Lancaster · 2023 to 2026
$2.4M
Mayo Clinic Kogod Center on Aging UL1R002377NIA NIH HHS R01 AG080037NIH HHS R01AG080037
6 · The paper itself

Abstract

Weakened germinal center responses by the aged immune system result in diminished immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between activated B cells and CD4

Indexed as

CD40 LigandCell DifferentiationProto-Oncogene Proteins c-bcl-6AgingAnimalsCellular MicroenvironmentFemaleGerminal CenterMaleMiceMice, Inbred C57BLT Follicular Helper CellsT-Lymphocytes, Helper-InducerBcl6 protein, mouseCD40 LigandProto-Oncogene Proteins c-bcl-6aginggerminal centerT follicular helper cells

Identifiers

PMID38481058
PMCPMC11296098
OpenAlexW4392814092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.