ArticleNature2024
APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 374 papers.
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374citing papers in PubMed
236.0field-weighted citation impact, top 1% of its field
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Who cites it
374 citing papers in PubMed, 414 citations in OpenAlex.
- Pulse pressure as a predictor of Alzheimer's disease biomarkers and cognitive decline: The moderating role of APOE ε4.The journal of prevention of Alzheimer's disease · 2025Trial
- Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies.The Lancet. Neurology · 2026Article
- Exercise promotes lipophagy and mitigates cognitive impairment in Alzheimer's disease through downregulating microglial TMEM9.Translational neurodegeneration · 2026Article
- Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk.Annals of neurology · 2026Article
- miR-214-3p and NCKAP1: A microglial functional dimension of Alzheimer's progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- ApoE lipidation state directs immunometabolic reprogramming of human microglia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lipophagy and lipid droplets in neurodegeneration.Trends in pharmacological sciences · 2026Review
- Targeting cytokine-driven neuroinflammation in Alzheimer's disease: mechanistic insights and pharmacological strategies.Inflammopharmacology · 2026Review
- Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nutritional Status and Cognition in Older Adults: Modification by Apolipoprotein E ε4.Nutrients · 2026Article
- DHA deficiency drives neural oxidized-lipid stress and microglial activation.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal AdipoR1 regulates the microglial response and delays disease progression in a mouse model of Alzheimer's disease.Molecular psychiatry · 2026Article
- Neuronal and Astrocytic Lipid Metabolic Coupling Mediates Ozone-Induced Learning and Memory Impairment.Environment & health (Washington, D.C.) · 2026Article
- Epigenomic Remodeling by Lipid Metabolism: A Cross-Disease Perspective on Cancer and Brain Disorders.Genes · 2026Review
- Age-dependent changes in lipid droplet distribution and vascularization in naked mole rat vs. mouse hippocampus.GeroScience · 2026Article
- Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria.Nature communications · 2026Article
- Progressive behavioral and cognitive decline inbioRxiv : the preprint server for biology · 2026Article
- Human iPSC models revealResearch square · 2026Article
- Quinex: Quantitative information extraction from text using open and lightweight LLMs.Innovation (Cambridge (Mass.)) · 2026Article
- Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains.Cell stem cell · 2026Article
314 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 7 institutions in 1 country.
Michael S Haney *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Róbert Pálovics *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Christy Nicole MunsonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Chris LongDepartment of Materials Science & Engineering Department, Stanford University School of Medicine, Stanford, CA, USA.
Patrik K JohanssonDepartment of Materials Science & Engineering Department, Stanford University School of Medicine, Stanford, CA, USA.
Oscar YipGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0001-9096-7167
Wentao DongThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.ORCID 0000-0001-5490-4265
Eshaan RawatThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
Elizabeth WestDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA, USA.
Johannes C M SchlachetzkiDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0002-7801-9743
Andy TsaiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6400-544X
Ian Hunter GuldnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Bhawika S LamichhaneDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8795-7053
Amanda SmithDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nicholas SchaumDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Kruti CalcuttawalaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Andrew ShinDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3903-1432
Yung-Hua WangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Chengzhong WangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Nicole KoutsodendrisGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-2761-1480
Geidy E SerranoLaboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
Thomas G BeachBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
Eric M ReimanBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA.ORCID 0000-0002-0705-3696
Christopher K GlassDevelopment and Stem Cell Biology Graduate Program, University of California, San Francisco, CA, USA.
Monther Abu-RemailehThe Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA.
Annika EnejderDepartment of Materials Science & Engineering Department, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2000-1353
Yadong HuangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-5871-4589
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.ORCID 0000-0001-5893-0831
Neurosciences Institute · USStanford University · USGladstone Institutes · USAlzheimer's Association · USUniversity of California San Diego · USBanner Sun Health Research Institute · USUniversity of California, San Francisco · US
Funding
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5MStanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Jennifer Kaci Fairchild · 2020 to 2026
$29.0MAPOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4MResearch Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI HEATHER Allyson BIMONTE-NELSON · 2021 to 2026
$24.9MProject 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI MUCKE, LENNART · 2021 to 2025
$23.4MTraining in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MStanford Medicine Center for Longevity and Healthy Aging Research Education CoreP30AG059307 · NIA · STANFORD UNIVERSITY · PI ZOU, JAMES · 2018 to 2025
$4.9MMicroglial lipid droplets in Alzheimer's diseaseRF1AG064928 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2019 to 2019
$3.7MImaging the metabolic and phagocytic landscape of microglia in Alzheimer’s diseaseR03AG071791 · NIA · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2021 to 2022
$315kNIA NIH HHS P01 AG073082NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG059307NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG069453NIA NIH HHS R03 AG071791NIA NIH HHS RF1 AG064928NIA NIH HHS T32 AG000266NINDS NIH HHS U24 NS072026
Abstract
Several genetic risk factors for Alzheimer's disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells
Indexed as
Alzheimer DiseaseApolipoprotein E4Lipid DropletsMicrogliaAmyloid beta-PeptidesAnimalsCoenzyme A LigasesCulture Media, ConditionedFemaleGenetic Predisposition to DiseaseHumansInduced Pluripotent Stem CellsMaleMicePhosphorylationtau ProteinsACSL1 protein, humanAmyloid beta-PeptidesApolipoprotein E4Coenzyme A LigasesCulture Media, Conditionedtau ProteinsTriglycerides
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