Evidence map›Paper›PMID 38480887›Full record

ArticleNature2024

Blueprinting extendable nanomaterials with standardized protein blocks.

Timothy F Huddy, Yang Hsia, Ryan D Kibler, Jinwei Xu, Neville Bethel, Deepesh Nagarajan, Rachel Redler, Philip J Y Leung, Connor Weidle, Alexis Courbet and 22 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Chemical reviews · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Inhibition of ice recrystallization with designed twistless helical repeat proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. De novo design of metal-oxide templating proteins.bioRxiv : the preprint server for biology · 2025
    Article
  13. Beyond evolution:Biosafety and health · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Timothy F Huddy *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5455-416X
Yang Hsia *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7467-8373
Ryan D Kibler *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6984-9887
Jinwei Xu *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Neville BethelDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7576-9613
Deepesh NagarajanM.S. Ramaiah University of Applied Sciences, Bengaluru, India.
Rachel RedlerDepartment of Cell Biology, NYU School of Medicine, New York, NY, USA.
Philip J Y LeungDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Connor WeidleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Alexis CourbetDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0539-7011
Erin C YangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Nicolas CoudrayDepartment of Cell Biology, NYU School of Medicine, New York, NY, USA.
S John CaliseDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5146-8629
Fatima A Davila-HernandezDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Hannah L HanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4787-5168
Kenneth D CarrDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0009-0005-1929-3952
Zhe LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9402-4940
Ryan McHughDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Gabriella ReggianoDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-3266-8131
Miles S DickinsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
T J BrunetteDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0748-8224
Yulai LiuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Justas DauparasDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Andrew J BorstDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Damian EkiertDepartment of Cell Biology, NYU School of Medicine, New York, NY, USA.ORCID 0000-0002-2570-0404
Justin M KollmanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0350-5827
Gira BhabhaApplied Bioinformatics Laboratories, NYU School of Medicine, New York, NY, USA.ORCID 0000-0003-0624-6178
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Unravelling lipid trafficking for the bacterial outer membraneR35GM128777 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Damian Ekiert · 2018 to 2026
$4.1M
Acquisition of a high resolution, high throughput cryo-electron microscopeS10OD023476 · OD · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M · 2017 to 2017
$2.0M
NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM128777NIGMS NIH HHS U24 GM129539NIH HHS S10 OD023476
6 · The paper itself

Abstract

A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in comparison, has been much more complex, largely owing to the irregular shapes of protein structures

Indexed as

NanostructuresProteinsCrystallography, X-RayMicroscopy, ElectronReproducibility of ResultsProteins

Identifiers

PMID38480887
PMCPMC10972742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.