ArticleNature2024
Evolutionary trajectories of small cell lung cancer under therapy.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
26.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Safety and efficacy of drug-eluting beads versus conventional bronchial arterial chemoembolization for lung cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Efficacy and biomarker exploration of anlotinib plus penpulimab in second-line ES-SCLC: Results from the phase 2 ALTER-L041 trial.Cell reports. Medicine · 2026Trial
- Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer.Biomarker research · 2026Review
- Rechallenge With Immunotherapy for ES-SCLC: Efficacy and Safety From a Retrospective Propensity Score-Matched Study.Cancer medicine · 2026Article
- Deconvolution of evolutionary architecture unmasks a high-risk, subclonal-rich subtype in treatment-naive small cell lung cancer.Journal of thoracic disease · 2026Article
- A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer.Molecular cancer · 2026Article
- Quantitative Immunohistochemical Landscapes and Chemoimmunotherapy Outcomes of ASCL1, NEUROD1, POU2F3, and YAP1 in Pure Small-Cell Lung Cancer: A Pilot Study.Journal of clinical medicine · 2026Article
- YAP1 Defines an Emergent, Plastic Population of Relapsed SCLC.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Article
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Article
- Transcriptional evidence of neuroendocrine cell plasticity beyond histological boundaries in lung neuroendocrine neoplasms: an in-silico analysis suggesting a progression model.Journal of experimental & clinical cancer research : CR · 2026Article
- Bridging the Gap in Lung Cancer: Novel Biomarkers, Metabolic Drivers, and Advanced Therapeutics from Bench to Bedside.Biomedicines · 2026Article
- Radiomics-Based Prediction of Treatment Response in Non-Small Cell Lung Cancer Using Pre-Treatment CT Imaging Features.Diagnostics (Basel, Switzerland) · 2026Article
- LeafRank: A phylodynamic framework for inferring relative fitness from single-cell phylogenies in chromosomally unstable tumors.bioRxiv : the preprint server for biology · 2026Article
- Tumor cells escape from therapy-induced senescence: from molecular mechanisms to targeted intervention.Biology direct · 2026Review
- Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer.Nature communications · 2026Article
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- Transformation or Clonal Evolution? A Rare Case Report of Pulmonary Sarcomatoid Carcinoma Developing to Small Cell Lung Cancer.Thoracic cancer · 2026Article
- Mechanisms of resistance in small cell lung cancer.Chinese medical journal · 2026Review
- Survival outcomes and molecular predictors in small cell lung cancer with brain metastases receiving immunotherapy.Journal of neuro-oncology · 2026Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors at 20 institutions in 3 countries.
Julie GeorgeDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. jgeorge@uni-koeln.de.ORCID 0000-0002-4272-3683
Lukas MaasDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-5830-6710
Nima AbedpourDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-2933-8035
Maria CartolanoDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Laura KaiserDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3212-576X
Rieke N FischerDepartment I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany.
Andreas H ScheelInstitute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-0244-1646
Jan-Philipp WeberDepartment I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany.
Martin HellmichInstitute of Medical Statistics, and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-5174-928X
Graziella BoscoDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Caroline VolzDepartment I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.
Christian MuellerDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Ilona DahmenDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Felix JohnDepartment I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany.
Cleidson Padua AlvesDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Lisa WerrDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3697-4136
Jens Peter PanseDepartment of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
Martin KirschnerDepartment of Haematology, Oncology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
Walburga Engel-RiedelDepartment of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany.
Jessica JürgensDepartment of Pneumology, City of Cologne Municipal Hospitals, Lung Hospital Cologne Merheim, Cologne, Germany.
Erich StoelbenThoraxclinic Cologne, Thoracic Surgery, St. Hildegardis-Krankenhaus, Cologne, Germany.
Michael BrockmannDepartment of Pathology, City of Cologne Municipal Hospitals, Witten/Herdecke University, Cologne, Germany.
Stefan GrauDepartment of General Neurosurgery, Centre of Neurosurgery, University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-9742-527X
Martin SebastianDepartment of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Jan A StratmannDepartment of Medicine II, Haematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
Jens KernKlinikum Würzburg Mitte - Missioklinik site, Pneumology and Respiratory Medicine, Würzburg, Germany.
Horst-Dieter HummelTranslational Oncology/Early Clinical Trial Unit, Comprehensive Cancer Centre Mainfranken, University Hospital Wuerzburg, Wuerzburg, Germany.
Balazs HegedüsDepartment of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-4341-4153
Martin SchulerDKFZ, German Cancer Research Centre, German Cancer Consortium, Heidelberg, Germany.ORCID 0000-0002-2166-3394
Till PlönesDepartment of Medical Oncology, West German Cancer Centre Essen, University Duisburg-Essen, Essen, Germany.
Clemens AignerDepartment of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.ORCID 0000-0002-7787-991X
Thomas ElterDepartment I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.
Karin ToepeltDepartment I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.
Yon-Dschun KoComprehensive Cancer Centre CIO Bonn, Bonn, Germany.
Sylke KurzDepartment of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany.
Christian GrohéDepartment of Respiratory Diseases, Evangelische Lungenklinik, Berlin, Germany.
Monika SerkeDGD Lungenklinik Hemer, Internal Medicine, Pneumology and Oncology, Hemer, Germany.
Katja HöpkerClinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Lars HagmeyerClinic of Pneumology and Allergology, Centre for Sleep Medicine and Respiratory Care, Bethanien Hospital Solingen, Solingen, Germany.
Fabian DoerrDepartment of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.
Khosro HekmathDepartment of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany.
Judith StrapatsasDepartment of Haematology, Oncology and Clinical Immunology, University Hospital of Duesseldorf, Düsseldorf, Germany.
Karl-Otto KambartelKrankenhaus Bethanien Moers, Moers, Germany.
Geothy ChakupurakalPraxis für Hämatologie und Onkologie, Koblenz, Germany.
Annette BuschMedical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany.
Franz-Georg BauernfeindMedical Clinic III for Oncology, Haematology, Immune-Oncology and Rheumatology, Centre for Integrative Medicine, University Hospital Bonn, Bonn, Germany.
Frank GriesingerPius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany.
Anne LuersPius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany.
Wiebke DirksPius-Hospital Oldenburg, Department of Haematology and Oncology, University Department Internal Medicine-Oncology, University Medicine Oldenburg, Oldenburg, Germany.
Rainer WiewrodtPulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany.
Andrea LueckePulmonary Division, Department of Medicine A, Münster University Hospital, Münster, Germany.
Ernst RodermannOnkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany.
Andreas DielOnkologie Rheinsieg, Praxisnetzwerk Hämatologie und Internistische Onkologie, Troisdorf, Germany.
Volker HagenClinic II for Internal Medicine, St.-Johannes-Hospital Dortmund, Dortmund, Germany.
Kai SeverinHaematologie und Onkologie Köln MV-Zentrum, Cologne, Germany.
Roland T UllrichDepartment I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University Hospital Cologne, Cologne, Germany.
Hans Christian ReinhardtDepartment of Haematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.
Alexander QuaasInstitute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany.
Magdalena BogusInstitute of Legal Medicine, University of Cologne, Cologne, Germany.
Cornelius CourtsInstitute of Legal Medicine, University of Cologne, Cologne, Germany.ORCID 0000-0002-9811-8482
Peter NürnbergCologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany.ORCID 0000-0002-7228-428X
Kerstin BeckerCologne Centre for Genomics, West German Genome Centre, University of Cologne, Cologne, Germany.ORCID 0009-0009-7897-7181
Viktor AchterComputing Centre, University of Cologne, Cologne, Germany.ORCID 0000-0002-3813-0746
Reinhard BüttnerInstitute of Pathology, Medical Faculty, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-8806-4786
Jürgen WolfDepartment I of Internal Medicine, Lung Cancer Group Cologne, University Hospital Cologne, Cologne, Germany.
Martin PeiferDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. mpeifer@uni-koeln.de.ORCID 0000-0002-5243-5503
Roman K ThomasDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. roman.thomas@uni-koeln.de.ORCID 0000-0001-9132-4876
University of Cologne · DEUniversity Hospital Cologne · DEDüsseldorf University Hospital · DEPius Hospital Oldenburg · DEPraxis für Hämatologie und Onkologie · DEEvangelische Lungenklinik Berlin · DEGerman Cancer Research Center · DEGoethe University Frankfurt · DEIntegrated Oncology (United States) · USKrankenhaus Bethanien · DERuhrlandklinik · DEUniversity Hospital Bonn · DEUniversity Hospital Münster · DEComprehensive Cancer Center Mainfranken · DEEssen University Hospital · DEFulda University of Applied Sciences · DEKlinikum Würzburg Mitte · DELungenklinik Hemer · DESt.-Johannes-Hospital Dortmund · DETH Köln - University of Applied Sciences · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown
Indexed as
Evolution, MolecularImmunotherapyLung NeoplasmsPlatinumSmall Cell Lung CarcinomaAnimalsClone CellsCREB-Binding ProteinDrug Resistance, NeoplasmE1A-Associated p300 ProteinFemaleForminsGenes, mycHumansMaleMiceCREB-Binding ProteinCREBBP protein, humanE1A-Associated p300 ProteinEP300 protein, humanFmn2 protein, humanForminsNuclear ProteinsPlatinumRB1 protein, humanRetinoblastoma Binding ProteinsTP53 protein, humanTP73 protein, humanTumor Protein p73Tumor Suppressor Protein p53Ubiquitin-Protein Ligases
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