ArticleNature2024
Time-resolved cryo-EM of G-protein activation by a GPCR.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81citing papers in PubMed
–field-weighted citation impact
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Who cites it
81 citing papers in PubMed.
- A Minimalist Model for Navigating Conformational Landscape Uncovers the Activation Mechanism of βACS physical chemistry Au · 2026Article
- From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1‑GACS omega · 2026Article
- New paradigm of q-CAR drug development targeting disease-specific protein conformations.npj drug discovery · 2026Review
- Protein Frustration Reveals Orthosteric and Allosteric Active Sites in GPCR:G Protein Complexes.Journal of chemical information and modeling · 2026Article
- The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel.Acta pharmacologica Sinica · 2026Review
- Article
- Conserved residues in the Gα interface show subtype specificity in Gβγ coupling.The Journal of biological chemistry · 2026Article
- From possibility to precision in macromolecular ensemble prediction.Nature methods · 2026Article
- Article
- Targeting tumor-associated G-protein coupled receptors: beyond single-axis inhibition toward multidimensional regulation.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Tool antibody fragments reveal multiple conformations of the rhodopsin-Gi signaling complex.Biophysical journal · 2026Article
- An integrated experimental and computational pipeline for crystallographic fragment screening of membrane protein in the lipid cubic phase.Communications chemistry · 2026Article
- Determinants of drug efficacy and the dynamics of G protein activation.Nature structural & molecular biology · 2026Article
- Structural Mechanism of an Efficacy Photoswitch Targeting the βAngewandte Chemie (International ed. in English) · 2026Article
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- Article
- Article
- Structural basis of Neisseria meningitidis quinol dependent nitric oxide reductase activation by dimerization.Communications biology · 2026Article
- Counting particles in cryo-electron microscopy may result in incorrect population estimates.Communications biology · 2026Article
- Mapping partial agonism of mitragynine at the µ-opioid receptor through molecular dynamics and Markov state modelling analysis.Scientific reports · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
15 authors.
Makaía M Papasergi-ScottDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3238-3213
Guillermo Pérez-HernándezCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany.ORCID 0000-0002-9287-8704
Hossein BatebiInstitute of Medical Physics and Biophysics, Faculty of Medicine, Leipzig University, Leipzig, Germany.ORCID 0000-0002-0714-9700
Yang GaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8758-0954
Gözde EskiciDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Alpay B SevenDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Ouliana PanovaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5089-620X
Daniel HilgerDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5179-1357
Marina CasiraghiDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Feng HeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6286-8134
Luis MaulDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Peter GmeinerDepartment of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-4127-197X
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5958-3990
Peter W HildebrandCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany.ORCID 0000-0003-0063-1104
Georgios SkiniotisDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.ORCID 0000-0003-0238-7846
Funding
Structure and dynamics of G protein coupled receptor-G protein complexesR01GM083118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOBILKA, BRIAN K, SKINIOTIS, GEORGIOS · 2008 to 2023
$8.3MTHE MECHANISM OF BETA2 ADRENOCEPTOR ACTIVATIONR01NS028471 · NINDS · STANFORD UNIVERSITY · PI KOBILKA, BRIAN K · 1990 to 2021
$6.7MG protein coupled receptor structure, dynamics, and signaling.R35NS137408 · NINDS · STANFORD UNIVERSITY · PI Brian K Kobilka · 2024 to 2026
$1.9MSpatiotemporal visualization of adenylyl cyclase signalingK99HL161406 · NHLBI · STANFORD UNIVERSITY · PI PAPASERGI, MAKAIA M. · 2023 to 2024
$284kNHLBI NIH HHS K99 HL161406NIGMS NIH HHS R01 GM083118NINDS NIH HHS R01 NS028471NINDS NIH HHS R35 NS137408
Abstract
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating guanine nucleotide exchange in the Gα subunit
Indexed as
Cryoelectron MicroscopyGTP-Binding Protein alpha Subunits, GsReceptors, Adrenergic, beta-2Binding SitesEnzyme ActivationGuanosine TriphosphateHumansModels, MolecularMolecular Dynamics SimulationProtein BindingProtein DomainsProtein Structure, SecondarySignal TransductionTime FactorsGTP-Binding Protein alpha Subunits, GsGuanosine TriphosphateReceptors, Adrenergic, beta-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.