ArticleNature2024
Mitochondrial complex I activity in microglia sustains neuroinflammation.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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0cells of the map it votes in
119citing papers in PubMed
43.8field-weighted citation impact, top 1% of its field
What it found
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Who cites it
119 citing papers in PubMed, 177 citations in OpenAlex.
- A lesion-responsive ZIF-8/zinc-myricetin nano-biointerface remodels mitochondrial-immune crosstalk for spinal cord repair.Materials today. Bio · 2026Article
- Dynamic metabolic programming of monocyte-derived cells defines immunity in CNS disease.Brain : a journal of neurology · 2026Review
- T-cell activity feedback-guided photothermal immunotherapy enabled by immune-responsive redox nanodots.Materials today. Bio · 2026Article
- Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy.CNS neuroscience & therapeutics · 2026Review
- H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration.The Journal of clinical investigation · 2026Review
- Article
- Targeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- Longitudinal analysis reveals myeloid cell contributions to murine neuroPASC pathogenesis.Nature communications · 2026Article
- Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism.Translational neurodegeneration · 2026Article
- First Total-Body Kinetics Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Mitochondrial reactive oxygen species regulate HIF-1α stabilization and methylglyoxal accumulation in classically activated mouse macrophages.Immunometabolism (Cobham, Surrey) · 2026Review
- Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis.EBioMedicine · 2026Article
- Microglial CARD19 ameliorates post-stroke neuroinflammation by stabilizing mitochondrial cristae.Neural regeneration research · 2026Article
- Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation.Nature immunology · 2026Article
- Microglial dysregulation and spatiotemporal dynamics of inflammation in multiple sclerosis white matter: an integrative transcriptomic analysis.Journal of translational medicine · 2026Article
- Advancing MSC-EV Therapies: Harnessing Preconditioning and Mito-EVs to Tackle Neuroinflammation and Neurodegeneration.Pharmaceutics · 2026Review
- Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice.Nature communications · 2026Article
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 8 institutions in 5 countries.
L Peruzzotti-Jametti *Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK. lp429@cam.ac.uk.ORCID 0000-0002-9396-5607
C M Willis *Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
G Krzak *Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
R HamelDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0013-6226
L PirvanWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
R-B IonescuDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4488-5467
J A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.
H A PragMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-4753-8567
M E Garcia-SeguraDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
V WuDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Y XiangDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
B BarlasDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
A M CaseyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0002-7242-3251
A M R van den BoschDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
A M NicaiseDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7160-5988
L RothDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
G R BatesMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
H HuangDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
P PrasadDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.ORCID 0009-0005-7446-0151
A E VincentWellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
C FrezzaUniversity Hospital Cologne, Cologne, Germany.ORCID 0000-0002-3293-7397
C ViscomiUniversity of Padua, Padova, Italy.ORCID 0000-0001-6050-0566
G BalmusDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2872-4468
Z TakatsDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-0795-3467
J C MarioniEuropean Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-9092-0852
A D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-2258-6490
M P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0003-1115-9618
I MohorianuWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4863-761X
S PluchinoDepartment of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK. spp24@cam.ac.uk.ORCID 0000-0002-6267-9472
University of Cambridge · GBImperial College London · GBUniversity of Colorado Denver · USWellcome/MRC Cambridge Stem Cell Institute · GBEuropean Bioinformatics Institute · GBUniversity Hospital Cologne · DEUniversity of Padua · ITWellcome Centre for Mitochondrial Research · GB
Funding
Resuscitation Strategies for Achieving Thrombo-inflammatory HomeostasisRM1GM131968 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI COHEN, MITCHELL, D'ALESSANDRO, ANGELO · 2019 to 2023
$11.3MThe Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9MThe role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4MThe paradoxical response to iron in pulmonary hypertension of sickle cell diseaseR01HL161004 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, D'ALESSANDRO, ANGELO · 2022 to 2025
$2.7MInteractions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6MMIRAGES: Metabolic Investigation of Red blood cells as a function of Aging, Genetics, Environment, and StorageR21HL150032 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2021
$414kNHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R01 HL161004NHLBI NIH HHS R21 HL150032NIGMS NIH HHS RM1 GM131968Wellcome Trust
Abstract
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis
Indexed as
Electron Transport Complex IInflammationMicrogliaNeuroinflammatory DiseasesAnimalsCentral Nervous SystemDisease Models, AnimalElectron TransportFemaleHumansMaleMiceMitochondriaMultiomicsMyeloid CellsReactive Oxygen SpeciesElectron Transport Complex IReactive Oxygen Species
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.