Evidence map›Paper›PMID 38480774›Full record

ArticleScientific reports2024

Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells.

Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  7. Natural and Engineered Cytokines as Cancer Therapeutics.Annual review of cancer biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Zhi-Liang Jing *Department of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China.
Guang-Long Liu *Department of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China.
Na Zhou *Department of Pathology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, 510120, China.
Dong-Yan Xu *Department of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China.
Na FengDepartment of Pathology, Dongguan Songshan Lake Tungwah Hospital, Dongguan, 523413, China.
Yan LeiDepartment of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China.
Li-Li MaDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Min-Shan TangDepartment of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China.
Gui-Hui TongDepartment of Pathology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510415, China.
Na TangDepartment of Pathology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, China. tangna1225@163.com.
Yong-Jian DengDepartment of Pathology, School of Basic Medical Sciences and Nan Fang Hospital, Southern Medical University, Guangzhou, 510515, China. briandeng@163.com.
Key Laboratory of Guangdong Province · CNSouthern Medical University · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CNGuangdong Provincial People's Hospital · CNGuangzhou Medical University · CNJinan University · CNSongshan Lake Materials Laboratory · CN

Funding

the National Natural Science Foundation of China 81672453the National Natural Science Foundation of China 81702359
6 · The paper itself

Abstract

The bioactivity of interferon-γ (IFN-γ) in cancer cells in the tumor microenvironment (TME) is not well understood in the current immunotherapy era. We found that IFN-γ has an immunosuppressive effect on colorectal cancer (CRC) cells. The tumor volume in immunocompetent mice was significantly increased after subcutaneous implantation of murine CRC cells followed by IFN-γ stimulation, and RNA sequencing showed high expression of B7 homologous protein 4 (B7H4) in these tumors. B7H4 promotes CRC cell growth by inhibiting the release of granzyme B (GzmB) from CD8

Indexed as

Colorectal NeoplasmsT-Lymphocytes, CytotoxicAnimalsCD8-Positive T-LymphocytesHumansInterferon-gammaMiceTumor MicroenvironmentInterferon-gammaB7H4CD8+ T cellsColorectal cancerIFN-γImmune cytotoxicityTumor microenvironment

Identifiers

PMID38480774
PMCPMC10937991
OpenAlexW4392752364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.