ArticleNature communications2024
Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 6 citations in OpenAlex.
- Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy.Epilepsia open · 2026Article
- A geometry aware framework enhances noninvasive mapping of whole human brain dynamics.Nature biomedical engineering · 2026Article
- Altered salience network structure-function integration underlies the decline in cognitive flexibility during aging.PLoS biology · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
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Abstract
Deciphering the complex relationship between neuroanatomical connections and functional activity in primate brains remains a daunting task, especially regarding the influence of monosynaptic connectivity on cortical activity. Here, we investigate the anatomical-functional relationship and decompose the neuronal-tracing connectome of marmoset brains into a series of eigenmodes using graph signal processing. These cellular connectome eigenmodes effectively constrain the cortical activity derived from resting-state functional MRI, and uncover a patterned cellular-functional decoupling. This pattern reveals a spatial gradient from coupled dorsal-posterior to decoupled ventral-anterior cortices, and recapitulates micro-structural profiles and macro-scale hierarchical cortical organization. Notably, these marmoset-derived eigenmodes may facilitate the inference of spontaneous cortical activity and functional connectivity of homologous areas in humans, highlighting the potential generalizing of the connectomic constraints across species. Collectively, our findings illuminate how neuronal-tracing connectome eigenmodes constrain cortical activity and improve our understanding of the brain's anatomical-functional relationship.
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