ArticleNature communications2024
An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Sex-Specific Associations Between Per- and Polyfluoroalkyl Substances and the Risk of Type 2 Diabetes: The Role of Genetic Susceptibility and Lipid Metabolism.Environmental health perspectives · 2026Article
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Associations of serum per- and polyfluoroalkyl substances (PFAS) mixture with the risk of chronic diseases: evidence from single‑ , multi-pollutant, and machine learning models.Archives of toxicology · 2026Article
- Associations between pyrethroid insecticide concentrations and dyslipidemia: Findings from the Dongfeng-Tongji cohort.Science advances · 2026Article
- Column switching liquid chromatography dual mass spectrometry system for simultaneous untargeted metabolomics and targeted exposomics.Nature communications · 2026Article
- Beyond AI-Driven Curve Fitting: Mechanistic Insight as the Cornerstone of Reliable Sensing and Accurate Fitting.Small methods · 2026Article
- Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS).Environmental science & technology · 2026Review
- Review
- An atlas of exposome-phenome associations in health and disease risk.Nature medicine · 2026Article
- Non-targeted screening of per- and polyfluoroalkyl substances: Advanced methods, challenges, and environmental health.Eco-Environment & Health · 2026Review
- Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of cardiometabolic diseases: Unraveling the mediating role of inflammatory markers.Eco-Environment & Health · 2026Article
- Retrieval-Augmented Language Models Enable Scalable Chemical Source Classification in Metabolomics Workflows.Analytical chemistry · 2026Article
- An overview of the impact of PFAS on animals, humans, and the environment using a One Health approach.Environmental science and pollution research international · 2026Review
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Persistent Organic Pollutants and Heart Rate Variability: A Population-Based Cross-Sectional Study in China.Journal of the American Heart Association · 2025Article
- Integrating the genome and exposome for precision health in Kuwait.Nature reviews. Genetics · 2025Article
- Quantitative Exposomics Targeting over 200 Toxicants and Key Biomarkers at the Picomolar Level.Environmental science & technology · 2025Article
- [Serum levels of polycyclic aromatic hydrocarbons and health risk assessment among children and adolescents].Se pu = Chinese journal of chromatography · 2025Article
- Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of kidney function decline: Unraveling the mediating role of iron status.Ecotoxicology and environmental safety · 2025Article
- Expanding the chemical exposome using in-silico transformation analysis - an example using insecticides.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, and some of them exceed safe ranges. Multi-exposure models reveal significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provides a comprehensive human serum exposome atlas and disease risk information, which can guide subsequent in-depth cause-and-effect studies between environmental exposures and human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.