Evidence map›Paper›PMID 38479592›Full record

ArticleToxicology and applied pharmacology2024

Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis.

J Calvin Kouokam, Rachel M Speer, Idoia Meaza, Jennifer H Toyoda, Haiyan Lu, John Pierce Wise

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J Calvin KouokamWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA. Electronic address: j0kouo01@louisville.edu.
Rachel M SpeerWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA; Current address: Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM 87131, USA.
Idoia MeazaWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA.
Jennifer H ToyodaWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA.
Haiyan LuWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA.
John Pierce WiseWise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA.
University of Louisville · US

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
UOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1M
Chromosome Instability Drives Metal-Induced Lung CancerR35ES032876 · NIEHS · UNIVERSITY OF LOUISVILLE · PI John Pierce Wise · 2021 to 2026
$6.1M
PARTICULATE CR(VI) TOXICOLOGY IN HUMAN LUNG EPITHELIAL CELLS AND FIBROBLASTS (Admin Supplement/PA-17-055)R01ES016893 · NIEHS · UNIVERSITY OF SOUTHERN MAINE · PI WISE, JOHN PIERCE · 2009 to 2021
$5.1M
NIEHS NIH HHS P30 ES030283NIEHS NIH HHS R01 ES016893NIEHS NIH HHS R35 ES032876NIEHS NIH HHS T32 ES011564NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

Hexavalent chromium [Cr(VI)] is considered a major environmental health concern and lung carcinogen. However, the exact mechanism by which Cr(VI) causes lung cancer in humans remains unclear. Since several reports have demonstrated a role for inflammation in Cr(VI) toxicity, the present study aimed to apply transcriptomics to examine the global mRNA expression in human lung fibroblasts after acute (24 h) or prolonged (72 and 120 h) exposure to 0.1, 0.2 and 0.3 μg/cm

Indexed as

ChromiumFibroblastsLungTranscriptomeCarcinogenesisCell LineChromatesGene Expression ProfilingHumansInflammationLung NeoplasmsSignal TransductionZinc CompoundsChromatesChromiumchromium hexavalent ionzinc chromateZinc CompoundsHexavalent ChromiumInflammationLung cancerTranscriptomics

Identifiers

PMID38479592
PMCPMC11069317
OpenAlexW4392663779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.