ArticleCell host & microbe2024
Pathophysiology of chikungunya virus infection associated with fatal outcomes.
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Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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64citing papers in PubMed, 3 pooled it
36.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Maternal Chikungunya virus infection and pregnancy outcomes: a global systematic review and meta-analysis of vertical transmission dynamics and associated morbidity.Emerging microbes & infections · 2026Pooled it
- Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review.Pathogens (Basel, Switzerland) · 2026Pooled it
- Visualized analysis of core themes and emerging frontiers in global chikungunya virus studies.Frontiers in microbiology · 2025Pooled it
- Modulating Chikungunya and Mayaro virus-induced disease severity in mice using low concentrations of anti-IFNAR1 antibodies.Emerging microbes & infections · 2026Article
- A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus.Virulence · 2026Article
- Research progress on the role of host factors in Chikungunya virus infection and intervention strategies.Virulence · 2026Review
- Glutamine antagonist DON attenuates chikungunya virus-induced myositis by suppressing inflammatory activation in a murine model.Emerging microbes & infections · 2026Article
- Review
- Cytokine profiles in Chikungunya virus-infected patients in Myanmar: a first report.Tropical medicine and health · 2026Article
- Expert Recommendations to Strengthen Chikungunya Outbreak Surveillance and Reporting for Traveler Health Protection.The American journal of tropical medicine and hygiene · 2026Article
- Characterization of an immunocompetent, young adult mouse model for studying chikungunya virus neuroinvasion and central nervous system infection.PLoS pathogens · 2026Article
- Identification and characterization of novel chikungunya virus polymerase inhibitors.Journal of virology · 2026Article
- Research advances in chikungunya virus: Epidemiology, pathogenesis, and control.One health (Amsterdam, Netherlands) · 2026Review
- Pathogens of the human central nervous system-the major viral pathogens.Journal of neurovirology · 2026Review
- Article
- Clinical, Virological, and Pathological Outcomes Associated with Viral Dose in AG129 Mice Infected with Chikungunya Virus: An In Vivo Model to Study Viral Pathogenesis and Antiviral Preclinical Evaluation.Pathogens (Basel, Switzerland) · 2026Article
- Distinct inflammatory biomarkers associated with rheumatological outcomes in chronic chikungunya disease.Scientific reports · 2026Article
- Overview of Chikungunya Virus Pathogenesis, Genome Variation, Epidemiology, and Control.Virus research · 2026Review
- Review
- Clinical characteristics and mortality of critically ill patients with chikungunya infection: a multicenter study in Paraguay.BMC infectious diseases · 2026Observational
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 10 institutions in 4 countries.
William M de SouzaDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, KY, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA; Global Virus Network, Baltimore, MD, USA. Electronic address: wmdesouza@uky.edu.
Marcilio J FumagalliLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Shirlene T S de LimaLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Pierina L PariseLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Deyse C M CarvalhoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; Laboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Cristian HernandezDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA.
Ronaldo de JesusCoordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Brazil; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jeany DelafioriInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Darlan S CandidoMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK; Department of Zoology, University of Oxford, Oxford, UK; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Victor C CarregariDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Stefanie P MuraroLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Gabriela F SouzaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Leda M Simões MelloLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Ingra M ClaroMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Yamilka DíazDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama, Panama.
Rodrigo B KatoCoordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Brazil; Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Lucas N TrentinInstitute of Chemistry and Center for Computing in Engineering and Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Clauber H S CostaInstitute of Chemistry and Center for Computing in Engineering and Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Ana Carolina B M MaximoLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Karene F CavalcanteLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Tayna S FiuzaLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil; Programa de Pós Graduação em Bioinformática, Instituto Metrópole Digital, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Vânia A F VianaLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Maria Elisabeth L MeloLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Clarissa P M FerrazLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Débora B SilvaLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Larissa M F DuarteLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Priscilla P BarbosaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Mariene R AmorimLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Carla C JudiceLaboratory of Tropical Diseases, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Daniel A Toledo-TeixeiraLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Mariana S RamundoInstituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Patricia V AguilarDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA; Center for Tropical Diseases, Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Emerson L L AraújoCoordenação Geral de Atenção às Doenças Transmissíveis na Atenção Primária, Departamento de Gestão ao cuidado Integral, Secretaria de Atenção Primária à Saúde, Ministério da Saúde, Brasília, Brazil.
Fabio T M CostaLaboratory of Tropical Diseases, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Thiago Cerqueira-SilvaUniversidade Federal da Bahia, Faculdade de Medicina, Salvador, Bahia, Brazil; Fundação Oswaldo Cruz, Instituto Gonçalo Muniz, Laboratório de Medicina e Saúde Pública de Precisão, Salvador, Bahia, Brazil.
Ricardo KhouriUniversidade Federal da Bahia, Faculdade de Medicina, Salvador, Bahia, Brazil; Fundação Oswaldo Cruz, Instituto Gonçalo Muniz, Laboratório de Medicina e Saúde Pública de Precisão, Salvador, Bahia, Brazil.
Viviane S BoaventuraUniversidade Federal da Bahia, Faculdade de Medicina, Salvador, Bahia, Brazil; Fundação Oswaldo Cruz, Instituto Gonçalo Muniz, Laboratório de Medicina e Saúde Pública de Precisão, Salvador, Bahia, Brazil; Hospital Santa Izabel, Santa Casa de Misericórdia da Bahia, Serviço de Otorrinolaringologia, Salvador, Bahia, Brazil.
Luiz Tadeu M FigueiredoVirology Research Centre, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rong FangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Brechla MorenoDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama, Panama.
Sandra López-VergèsDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama, Panama; Sistema Nacional de Investigación from SENACYT, Panama, Panama.
Liana Perdigão MelloLaboratório Central de Saúde Pública do Ceará, Fortaleza, Ceará, Brazil.
Munir S SkafInstitute of Chemistry and Center for Computing in Engineering and Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Rodrigo R CatharinoInnovare Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
Fabiana GranjaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Biodiversity Research Centre, Federal University of Roraima, Boa Vista, Roraima, Brazil.
Daniel Martins-de-SouzaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; D'Or Institute for Research and Education, São Paulo, São Paulo, Brazil; Experimental Medicine Research Cluster, University of Campinas, Campinas, São Paulo, Brazil.
Jessica A PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.
Kenneth S PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA.
Ester C SabinoInstituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Michael S DiamondDepartments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Eliseo EugeninDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, USA.
José Luiz Proença-MódenaLaboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
Nuno R FariaMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK; Department of Zoology, University of Oxford, Oxford, UK; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Scott C WeaverDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA; Global Virus Network, Baltimore, MD, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual do Ceará · BRThe University of Texas Medical Branch at Galveston · USInstituto Conmemorativo Gorgas de Estudios de la Salud · PAImperial College London · GBRockefeller University · USSecretaria da Saúde · BRUniversidade Federal da Paraíba · BRUniversidade Federal de Minas Gerais · BRUniversity of Oxford · GB
Funding
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4MWest African Center for Emerging Infectious DiseasesU01AI151801 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Robert W Cross, Scott C Weaver · 2020 to 2026
$10.1MWorld Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5MRole of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2MRational development of a vaccine against tick-borne rickettsiosesR01AI163857 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FANG, RONG MEGAN · 2022 to 2025
$3.2MTrajectory of Vector-adaptive Chikungunya Virus EvolutionR01AI121452 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2020
$2.3MTargeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirsR01MH134761 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Eliseo A Eugenin · 2024 to 2026
$2.1MEvolution of Mayaro virus and its impact on transmission by urban vectorsR21AI179094 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AGUILAR, PATRICIA VERONICA · 2023 to 2024
$440kMechanisms by which rickettsiae subvert autophagy pathway in macrophagesR21AI151904 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FANG, RONG MEGAN · 2021 to 2022
$440kMedical Research Council MR/X020258/1NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI121452NIAID NIH HHS R01 AI163857NIAID NIH HHS R21 AI151904NIAID NIH HHS R21 AI179094NIAID NIH HHS R24 AI120942NIAID NIH HHS U01 AI151801NIMH NIH HHS R01 MH134761NINDS NIH HHS R01 NS105584Wellcome Trust
Abstract
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infection, central nervous system damage, and elevated serum levels of pro-inflammatory cytokines and chemokines compared with survivors. The histopathologic, metabolite, and proteomic signatures of CHIK deaths reveal hemodynamic disorders and dysregulated immune responses. The CHIKV East-Central-South-African lineage infecting our study population causes both fatal and survival cases. Additionally, CHIKV infection impairs the integrity of the blood-brain barrier, as evidenced by an increase in permeability and altered tight junction protein expression. Overall, our findings improve the understanding of CHIK pathophysiology and the causes of fatal infections.
Indexed as
Chikungunya FeverChikungunya virusAnimalsCytokinesHumansProteomicsCytokinesalphavirusarboviruscentral nervous system infectionchikungunya deathchikungunya virushemodynamic disordersinflammationmosquito-borne viruspathophysiology
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