Evidence map›Paper›PMID 38478792›Full record

ArticleNeurology2024

Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults.

Shahram Oveisgharan, Francine Grodstein, Arnold M Evia, Bryan D James, Ana W Capuano, Yi Chen, Konstantinos Arfanakis, Julie A Schneider, David A Bennett

Open access · greenAbstract read
In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shahram OveisgharanFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0001-6841-4830
Francine GrodsteinFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0002-2699-7051
Arnold M EviaFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Bryan D JamesFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0002-6104-8310
Ana W CapuanoFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Yi ChenFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0009-0005-1045-0501
Konstantinos ArfanakisFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0001-9705-597X
Julie A SchneiderFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0002-9482-1752
David A BennettFrom the Rush Alzheimer's Disease Center (S.O., F.G., A.M.E., B.D.J., A.W.C., Y.C., K.A., J.A.S., D.A.B.); Department of Neurological Sciences (S.O., A.W.C., J.A.S., D.A.B.); Department of Internal Medicine (F.G., B.D.J., Y.C.); Department of Diagnostic Radiology and Nuclear Medicine (A.M.E., K.A.), Rush University Medical Center; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology; and Department of Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.ORCID 0000-0003-3689-554X
Rush University Medical Center · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917
6 · The paper itself

Abstract

BACKGROUND AND

objectivesEpilepsy is 1 of the 3 most common neurologic diseases of older adults, but few studies have examined its underlying pathologies in older age. We examined the associations of age-related brain pathologies with epilepsy in older persons.

methodsClinical and pathologic data came from 2 ongoing clinical pathologic cohort studies of community-dwelling older adults. Epilepsy was ascertained using Medicare fee-for-service Parts A and B claims data that were linked to data from the cohort studies. The postmortem pathologic assessment collected indices of 9 pathologies including Alzheimer disease, hippocampal sclerosis, macroinfarcts, and cerebral amyloid angiopathy. The fixed brain hemisphere was imaged using 3T MRI scanners before the pathologic assessments in a subgroup of participants.

resultsThe participants (n = 1,369) were on average 89.3 (6.6) years at death, and 67.0% were women. Epilepsy was identified in 58 (4.2%) participants. Cerebral amyloid angiopathy (odds ratio [OR] = 2.21, 95% CI 1.24-3.95, DISCUSSION: Cerebrovascular pathologies and cortical atrophy were associated with epilepsy in older persons.

Indexed as

Alzheimer DiseaseCerebral Amyloid AngiopathyEpilepsyHippocampal SclerosisAgedAged, 80 and overAtrophyAutopsyBrainFemaleHumansMaleMedicareUnited States

Identifiers

PMID38478792
PMCPMC11383919
OpenAlexW4392778594

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.