Evidence map›Paper›PMID 38478693›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Predictive phage therapy for

Marianne Keith, Alba Park de la Torriente, Antonia Chalka, Adriana Vallejo-Trujillo, Sean P McAteer, Gavin K Paterson, Alison S Low, David L Gally

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Rolling outMicrobial genomics · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Phage-Based Approaches to ChronicAntibiotics (Basel, Switzerland) · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Marianne Keith *The Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0003-2770-6241
Alba Park de la Torriente *The Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0009-0005-7751-4688
Antonia Chalka *The Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0001-7265-5960
Adriana Vallejo-TrujilloThe Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0003-3680-218X
Sean P McAteerThe Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0002-1257-2175
Gavin K PatersonThe Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0002-1880-0095
Alison S LowThe Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0002-8360-1316
David L GallyThe Roslin Institute, Division of Bacteriology, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID 0000-0002-2566-0844
Roslin Institute · GB

Funding

UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/D/20002173
6 · The paper itself

Abstract

This study supports the development of predictive bacteriophage (phage) therapy: the concept of phage cocktail selection to treat a bacterial infection based on machine learning (ML) models. For this purpose, ML models were trained on thousands of measured interactions between a panel of phage and sequenced bacterial isolates. The concept was applied to

Indexed as

BacteriophagesEscherichia coli InfectionsPhage TherapyUrinary Tract InfectionsAnimalsAnti-Bacterial AgentsEscherichia coliHumansAnti-Bacterial AgentsbacteriophageE. colimachine learningpredictive phage therapyUTI

Identifiers

PMID38478693
PMCPMC10962980
OpenAlexW4392739671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.