ArticleMethods in molecular biology (Clifton, N.J.)2024
Rationale in Custom Design of Transmembrane β-Barrel Pores.
Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Generative design of programmable asymmetric β-barrel nanopores.bioRxiv : the preprint server for biology · 2026Article
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Abstract
Biological nanopores incorporated into synthetic membranes are widely used for single-molecule analytical applications such as DNA sequencing. The ability to engineer custom membrane proteins with a pore would allow the generation of a multitude of nanopores for the sensing/sequencing of small molecules and (bio)polymers. The de novo design of transmembrane β-barrel pores has recently enabled the generation of nanopores with custom size, shape, and properties. In this chapter, I describe the rationale of transmembrane β-barrel design and computational methods to assemble the backbones, design sequences, and select the designs for experimental validation.
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