ArticleBrain imaging and behavior2024
Parkinson's disease CA2-CA3 hippocampal atrophy is accompanied by increased cholinergic innervation in patients with normal cognition but not in patients with mild cognitive impairment.
Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment.Brain and behavior · 2026Pooled it
- Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease.Annals of clinical and translational neurology · 2026Article
- Basal Forebrain Volume and Concurrent Hallucinations and Mild Cognitive Impairment in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Altered attention and visuospatial abnormalities in Parkinson's disease: links to attention networks and basal ganglia.Frontiers in aging neuroscience · 2026Article
- The Polynomial Progression Subtype Inference Algorithm.Research square · 2025Article
- A multicenter longitudinal study of cholinergic subgroups in Parkinson disease.Nature communications · 2025Article
- Nucleus Basalis of Meynert Volume and Cognitive Impairment in Parkinson's Disease Before and After Deep Brain Stimulation of the Subthalamic Nucleus.Brain sciences · 2025Article
- Cholinergic Basal Forebrain Integrity and Cognition in Parkinson's Disease: A Reappraisal of Magnetic Resonance Imaging Evidence.Movement disorders : official journal of the Movement Disorder Society · 2024Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although brain cholinergic denervation has been largely associated with cognitive decline in patients with Parkinson's disease (PD), new evidence suggests that cholinergic upregulation occurs in the hippocampus of PD patients without cognitive deficits. The specific hippocampal sectors and potential mechanisms of this cholinergic compensatory process have been further studied here, using MRI volumetry and morphometry coupled with molecular imaging using the PET radiotracer [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.