Evidence map›Paper›PMID 38478244›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Functional Assays in 3D ObaCell® Fat-on-a-Chip Cultures: Lipolysis and Glucose Uptake Assays.

Katie Hamel, Emma Rogers, Jeffrey M Gimble, Trivia Frazier, Cecilia Sanchez

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Anti-obesity peptides from food: Production, evaluation, sources, and commercialization.Comprehensive reviews in food science and food safety · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katie HamelObatala Sciences, Inc., New Orleans, LA, USA.
Emma RogersObatala Sciences, Inc., New Orleans, LA, USA.
Jeffrey M GimbleObatala Sciences, Inc., New Orleans, LA, USA.
Trivia FrazierObatala Sciences, Inc., New Orleans, LA, USA. trivia.frazier@obatalasciences.com.
Cecilia SanchezObatala Sciences, Inc., New Orleans, LA, USA.
Athens International Airport · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in three-dimensional in vitro cultures pose a need for modification of established two-dimensional culture functional assay methods. Application of three-dimensional in vitro models in drug screening and target validation, specifically in the development of compounds targeting adipose metabolic activity, requires optimization of current glucose uptake and lipolysis assay protocols to effectively measure adipocyte function in a three-dimensional platform. This chapter describes the establishment of three-dimensional cultures using Obatala Sciences' human-derived hydrogel, maintenance and treatment of the cultures, and evaluation of compound response via lipolysis and glucose uptake assays.

Indexed as

AdipocytesLipolysisGlucoseHumansLab-On-A-Chip DevicesObesityGlucoseFat-on-a-chipGlucose uptakeHuman-derived hydrogelLipolysisThree-dimensional cell culture

Identifiers

PMID38478244
OpenAlexW4392752150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.