ArticleHernia : the journal of hernias and abdominal wall surgery2024
Long-term results with biosynthetic absorbable P4HB mesh in ventral abdominal wall repair: a multicentre analysis.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- The Italian national consensus conference on the diagnosis and treatment of Rectus Abdominis diastasis in Post-gravidic Women.Hernia : the journal of hernias and abdominal wall surgery · 2025Pooled it
- Comparison of mesh infection management following ventral hernia repair with poly-4-hydroxybutyrate, synthetic, and biologic mesh: a retrospective review.Surgical endoscopy · 2026Article
- Comparative outcomes of bioabsorbable poly-4-hydroxybutyrate versus synthetic mesh in ventral hernia repair: A propensity-matched cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- A practical algorithm for the management of mesh infection in abdominal wall surgery: learnings after 20 years of experience.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Less pain and foreign body sensation after incisional hernia repair with partially absorbable mesh than with non-absorbable mesh: a retrospective sequential cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Editorial: Biosynthetic resorbable meshes: a New frontier in abdominal wall hernia repair.Frontiers in surgery · 2026Article
- Selective use of reinforced tissue matrix in complex abdominal wall reconstruction: a multicenter consensus analysis.Journal of abdominal wall surgery : JAWS · 2026Article
- Article
- Prevention of incisional hernia with biosynthetic mesh at the site of temporary ileostomy closure (PRINCESS Study): Preliminary Results.Hernia : the journal of hernias and abdominal wall surgery · 2025Observational
- Article
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Authors and funding
9 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this multicentre study was to analyse the outcomes of biosynthetic absorbable poly-4-hydroxybutyrate (P4HB) prosthesis implantation in patients undergoing ventral hernia repair (VHR) in the context of different degrees of contamination.
methodsFrom May 2016 to December 2021, a multicentre retrospective analysis of patients who underwent elective or urgent hernia repair with P4HB prosthesis was performed in seven hospitals in Spain and Portugal. Patients with a postoperative follow-up of less than 20 months and those within the theoretical period of prosthesis resorption were excluded from the study. Regarding the degree of contamination, patients were assessed according to the modified Ventral Hernia Working Group (VHWG) classification. Epidemiological data, hernia characteristics, surgical and postoperative variables (Clavien-Dindo classification) of these patients were analyzed. Risk factors related to long-term recurrence were studied by a multivariate analysis.
resultsIn 236 cases of P4HB prosthesis implantation, repair in cases of Grade 3 was the most frequent (49.1%), followed by Grade 2 in 42.3% of cases and Grade 1 in 8.4%. The most frequent complications were Grade 1, with the majority occurring during the first year. The overall rate of surgical site occurrences (SSO) was 30%. The hernia recurrence rate was 14.4% (n = 34), with a mean postoperative follow-up time of 41 months (22-61). The multivariate analysis showed that the onlay location of the mesh (OR 1.07; CI 1.42-2.70, p = 0.004) was a significant independent risk factor for recurrence.
conclusionsThe use of a P4HB bioresorbable mesh for the VHR with different degrees of contamination leads to favourable results overall, with an acceptable rate of hernia recurrence. The onlay location of the P4HB prosthesis is the main factor in recurrence in both elective and emergency settings.
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