Evidence map›Paper›PMID 38478179›Full record

Trial reportGeroScience2024

Resistance exercise effects on hippocampus subfield volumes and biomarkers of neuroplasticity and neuroinflammation in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial.

Wouter A J Vints, Julija Šeikinaitė, Evrim Gökçe, Simona Kušleikienė, Milda Šarkinaite, Kristina Valatkeviciene, Vida J Česnaitienė, Jeanine Verbunt, Oron Levin, Nerijus Masiulis

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Wouter A J VintsDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania. w.vints@maastrichtuniversity.nl.ORCID 0000-0003-1803-4949
Julija ŠeikinaitėDepartment of Rehabilitation, Physical and Sports Medicine, Institute of Health Science, Vilnius University, Vilnius, Lithuania.
Evrim GökçeSports Rehabilitation Laboratory, Ankara City Hospital, 06800, Ankara, Turkey.
Simona KušleikienėDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
Milda ŠarkinaiteDepartment of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Kristina ValatkevicieneDepartment of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Vida J ČesnaitienėDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
Jeanine VerbuntDepartment of Rehabilitation Medicine Research School CAPHRI, Maastricht University, Maastricht, The Netherlands.
Oron LevinDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
Nerijus MasiulisDepartment of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
Lithuanian Sports University · LTLithuanian University of Health Sciences · LTMaastricht University · NLMemorial Ankara Hospital · TRVilnius University · LT

Funding

Lietuvos Mokslo Taryba S-MIP-21-37
6 · The paper itself

Abstract

Physical exercise is suggested to promote hippocampal neuroplasticity by increasing circulating neurotrophic and anti-inflammatory factors. Our aim was to explore the interplay between the effect of progressive resistance exercise on blood biomarker levels, hippocampal neurometabolite levels and hippocampal volume in older adults with a low compared to a high risk of mild cognitive impairment (MCI). Seventy apparently healthy male/female older adults (aged 60-85 years old) were randomly allocated to a 12 week lower limb progressive resistance or no intervention, stratified for low (< 26/30) or high (≥ 26/30) Montreal Cognitive Assessment (MoCA) score, indicating MCI risk. Outcome measures were blood levels of insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6) or kynurenine (KYN); hippocampal total and subfield volumes of the cornu ammonis 1 (CA1) and 4 (CA4), subiculum, presubiculum, and dentate gyrus measured with magnetic resonance imaging (MRI); and hippocampus neurometabolites including total N-acetylaspartate (NAA), myo-inositol (mIns), and total creatine (Cr) measured with proton magnetic resonance spectroscopy (

Indexed as

BiomarkersCognitive DysfunctionHippocampusMagnetic Resonance ImagingNeuronal PlasticityResistance TrainingAgedAged, 80 and overAspartic AcidFemaleHumansInsulin-Like Growth Factor IInterleukin-6KynurenineMaleMiddle AgedAspartic AcidBiomarkersInsulin-Like Growth Factor IInterleukin-6KynurenineN-acetylaspartateCognitive agingHippocampusInflammationMyokinesNeurotrophic factorResistance exercise

Identifiers

PMID38478179
PMCPMC11226571
OpenAlexW4392763481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.