ArticleJournal of neurology2024
Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area.
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neurophysiological Characteristics of Nitrous Oxide-Induced Polyneuropathy: A Case Series.Journal of the peripheral nervous system : JPNS · 2026Article
- Rapid decline of elevated homocysteine level in nitrous oxide use.Scientific reports · 2026Article
- Social determinants of health in recreational nitrous oxide use: a narrative review.BMJ public health · 2026Review
- Nitrous Oxide Sourcing, Use and Harms: Insights From Australians Who Use Ecstasy/MDMA and Other Illicit Stimulants.Drug and alcohol review · 2025Article
- Nitrous oxide (N2O) recreational use is increasing across Germany - a survey of the German neurological society among practicing neurologists.Neurological research and practice · 2025Article
- Review
- Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial.Biological psychiatry global open science · 2025Article
- Critical insights for intensivists on Guillain-Barré syndrome.Annals of intensive care · 2025Review
- Neurological disorders caused by recreational use of nitrous oxide-a retrospective study from a German metropolitan area and review of the literature.Neurological research and practice · 2025Article
- [Life style drug laughing gas (nitrous oxide, NDer Nervenarzt · 2025Review
- Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?Addiction (Abingdon, England) · 2025Review
- Recreational nitrous oxide use in France in 2022: Results from a nationwide representative sample of adults.Drug and alcohol review · 2025Article
- Increase of nitrous oxide-induced neurological disorders - a German multicenter experience.Neurological research and practice · 2025Article
- Neurotoxicity mechanisms and clinical implications of six common recreational drugs.Frontiers in pharmacology · 2025Review
- Nitrous Oxide-Induced Vitamin B12 Deficiency and Myelopathy in Whippets Abusers: A Report of Two Cases.Cureus · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecreational nitrous oxide (N
methodsWe performed a retrospective multicentric cohort study of all adult patients with severe NI-NDs in the neurology and general internal medicine departments of the Greater Paris area from 2018 to 2021. The incidence was compared with that of non-NI-myelitis and Guillain-Barré syndrome (GBS) using a sample of 91,000 hospitalized patients sourced from health insurance data.
resultsAmong 181 patients, 25% had myelopathy, 37% had peripheral neuropathy and 38% had mixed disease. Most were aged between 20 and 25 years, lived in socially disadvantaged urban areas, and exhibited high rates of unemployment (37%). The incidence of NI-NDs increased during 2020 and reached a peak mid-2021. The 2021 incidence in 20-25-year-olds was 6.15 [4.72; 8.24] per 100,000 persons for NI-myelopathy and 7.48 [5.59; 9.37] for NI-peripheral neuropathy. This was significantly higher than for non-NI-myelitis (0.35 [0.02; 2.00]) and GBS (2.47 [0.64; 4.30]). The incidence of NI-NDs was two to three times higher in the most socially disadvantaged areas.
conclusionThe recent increase in recreational N
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