Evidence map›Paper›PMID 38477804›Full record

ArticleBrazilian oral research2024

EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features.

Mariana Saturnino de Noronha, Karolina Skarlet Silva Viana, Maria Cássia Ferreira de Aguiar, Cristiane Helena Squarize, Mauro Henrique Nogueira Guimarães de Abreu, Elismauro Francisco Mendonça, Vanessa de Fátima Bernardes

Open access · diamondAbstract read
In one paragraph

Article in Brazilian oral research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mariana Saturnino de NoronhaUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-9188-1939
Karolina Skarlet Silva VianaUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-6467-1434
Maria Cássia Ferreira de AguiarUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery and Pathology, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-5134-3466
Cristiane Helena SquarizeUniversity of Michigan, School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6782-3429
Mauro Henrique Nogueira Guimarães de AbreuUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Community and Preventive Dentistry, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-8794-5725
Elismauro Francisco MendonçaUniversidade Federal de Goiás - UFG, School of Dentistry, Department of Stomatologic Sciences, Goiânia, GO, Brazil.ORCID http://orcid.org/0000-0002-6751-3279
Vanessa de Fátima BernardesUniversidade Federal de Minas Gerais - UFMG, Biological Sciences Institute, Department of Pathology, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-0194-7434
Universidade Federal de Minas Gerais · BRUniversidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy.

Indexed as

Adenoma, PleomorphicCarcinoma, Adenoid CysticCell CycleCell ProliferationEnhancer of Zeste Homolog 2 ProteinHumansEnhancer of Zeste Homolog 2 ProteinEZH2 protein, human

Identifiers

PMID38477804
PMCPMC11376654
OpenAlexW4392695933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.