Evidence map›Paper›PMID 38477657›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.

Jessica A Palakshappa, Jane A E Batt, Sue C Bodine, Bronwen A Connolly, Jason Doles, Jason R Falvey, Lauren E Ferrante, D Clark Files, Michael O Harhay, Kirsten Harrell and 19 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Lung endothelial cytopathic tau is sufficient to impair long-term potentiation during infection.American journal of respiratory cell and molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Cognitive Reserve and Cluster Analysis: New Pieces in the Puzzle of Cognitive Impairment after ICU?American journal of respiratory and critical care medicine · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 5 countries.

Jessica A PalakshappaWake Forest University School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0002-6333-365X
Jane A E BattUniversity of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
Sue C BodineOklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Bronwen A ConnollyWellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, United Kingdom.ORCID 0000-0002-5676-5497
Jason DolesIndiana University School of Medicine, Indianapolis, Indiana.
Jason R FalveyUniversity of Maryland School of Medicine, Baltimore, Maryland.
Lauren E FerranteYale University School of Medicine, New Haven, Connecticut.ORCID 0000-0003-1345-1225
D Clark FilesWake Forest University School of Medicine, Winston-Salem, North Carolina.
Michael O HarhayUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0002-0553-674X
Kirsten Harrell
Joseph A HippensteelUniversity of Colorado School of Medicine, Aurora, Colorado.
Theodore J IwashynaJohns Hopkins University School of Medicine, Baltimore, Maryland.
James C JacksonVanderbilt University School of Medicine, Nashville, Tennessee.
Meghan B Lane-FallUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0001-7050-0017
Michelle MonjeHoward Hughes Medical Institute, Stanford University, Stanford, California.
Marc MossUniversity of Colorado School of Medicine, Aurora, Colorado.
Dale M NeedhamJohns Hopkins University School of Medicine, Baltimore, Maryland.
Matthew W SemlerVanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-7664-8263
Shouri LahiriCedars Sinai Medical Center, Los Angeles, California.
Lars LarssonCenter for Molecular Medicine, Karolinska Institute, Solna, Sweden.ORCID 0000-0003-3722-035X
Carla M SevinVanderbilt University School of Medicine, Nashville, Tennessee.
Tarek SharsharAnesthesia and Intensive Care Department, GHU Paris Psychiatry and Neurosciences, Institute of Psychiatry and Neurosciences of Paris, INSERM U1266, University Paris Cité, Paris, France.
Benjamin SingerUniversity of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-4721-6920
Troy StevensUniversity of South Alabama, Mobile, Alabama.
Stephanie P TaylorUniversity of Michigan, Ann Arbor, Michigan.
Christian R GomezDivision of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Guofei ZhouDivision of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Timothy D GirardCenter for Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-9833-4871
Catherine L HoughOregon Health & Science University, Portland, Oregon; and.
Vanderbilt University · USJohns Hopkins University · USNational Heart Lung and Blood Institute · USUniversity of Colorado Denver · USUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Toronto · CACedars-Sinai Medical Center · USHoward Hughes Medical Institute · USIndiana University School of MedicineInserm · FRKarolinska Institutet · SEOklahoma Medical Research Foundation · USOregon Health & Science University · USQueen's University Belfast · GBUniversity of Maryland, Baltimore · USUniversity of Pittsburgh · USUniversity of South Alabama · USWake Forest University · USYale University · US

Funding

CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL NetworkU01HL123009 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, THOMPSON, BOYD TAYLOR · 2014 to 2021
$67.2M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6M
Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
Prediction of Functional Outcomes from Chronic Critical IllnessR01NR016459 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CARSON, SHANNON S, DOUGLAS, IVOR SAMUEL · 2016 to 2020
$3.4M
Advancing the design, analysis, and interpretation of acute respiratory distress syndrome trials using modern statistical toolsR01HL168202 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Michael Oscar Harhay, Fan Li · 2023 to 2026
$2.9M
Effect of randomization to neuromuscular blockade on physical functional impairment and recovery in ARDSR01HL132232 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, IWASHYNA, THEODORE J · 2016 to 2019
$2.9M
Promoting Equity via Change in Practice for Respiratory Failure (PRECIPICE)R01HL157361 · NHLBI · NEW YORK UNIVERSITY · PI ARMSTRONG-HOUGH, MARI, VALLEY, THOMAS SEBASTIAN · 2022 to 2025
$2.7M
Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical OutcomesR01DK133177 · NIDDK · UNIVERSITY OF WASHINGTON · PI Pavan Kumar Bhatraju · 2022 to 2026
$2.6M
Soluble adenylyl cyclases in lung endothelial tauopathyR01HL167997 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Troy Stevens · 2023 to 2026
$1.9M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
Optimizing a self-directed mobile mindfulness intervention for improvingR01AT009974 · NCCIH · DUKE UNIVERSITY · PI COX, CHRISTOPHER ETHAN, HOUGH, CATHERINE LEE · 2021 to 2022
$1.4M
American Lung AssociationBLRD VA I01 BX005626Lung, and Blood Institute 5U01HL123009Lung, and Blood Institute K08HL159353Lung, and Blood Institute K24HL14152Lung, and Blood Institute R01HL157361National HeartNCATS NIH HHS KL2 TR002370NCCIH NIH HHS R01 AT009974NHLBI NIH HHS K08 HL159353NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R00 HL141678NHLBI NIH HHS R01 HL132232NHLBI NIH HHS R01 HL148069NHLBI NIH HHS R01 HL157361NHLBI NIH HHS R01 HL167997NHLBI NIH HHS R01 HL168202NHLBI NIH HHS U01 HL123009NIA NIH HHS K23 AG073529NIA NIH HHS K76 AG057023NIA NIH HHS K76 AG074926NIA NIH HHS K76AG074926NIA NIH HHS P30 AG021342NIA NIH HHS R03 AG074056NIA NIH HHS R21 AG079010NIDDK NIH HHS R01 DK133177NINR NIH HHS R01 NR016459
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproved. The NHLBI of the NIH assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation. The workshop included presentations by scientific leaders across the translational science spectrum and was open to the public as well as the scientific community. This report describes the themes discussed at the workshop as well as recommendations to advance the field toward the goal of improving the health and well-being of ARDS survivors.

Indexed as

Respiratory Distress SyndromeSurvivorsBrainHumansNational Heart, Lung, and Blood Institute (U.S.)Quality of LifeUnited Statescritical carerespiratory distress syndromesevere acute respiratory syndrome

Identifiers

PMID38477657
PMCPMC11146564
OpenAlexW4392740705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.