Evidence map›Paper›PMID 38477571›Full record

ReviewmBio2024

The impact of orphan histidine kinases and phosphotransfer proteins on the regulation of clostridial sporulation initiation.

Iman Mehdizadeh Gohari, Adrianne N Edwards, Shonna M McBride, Bruce A McClane

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Unique growth and morphology properties of Clade 5bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Iman Mehdizadeh Gohari *Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Adrianne N Edwards *Department of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia, USA.ORCID 0000-0002-2503-3787
Shonna M McBrideDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia, USA.ORCID 0000-0001-6221-714X
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-2451-5140
Emory University · USUniversity of Pittsburgh · US

Funding

MECHANISMS OF ACTION OF C PERFRINGENS EXTEROTOXINR01AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 1985 to 2024
$5.4M
Host-induced Initiation of Clostridium difficile SporulationR01AI116933 · NIAID · EMORY UNIVERSITY · PI SHONNA M. MCBRIDE · 2015 to 2026
$4.8M
Mechanisms of Action of C. Perfringens EnterotoxinR37AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 2005 to 2014
$3.0M
Mechanisms Underlying Nutrient-Mediated Sporulation in C. difficileR01AI156052 · NIAID · EMORY UNIVERSITY · PI MCBRIDE, SHONNA M. · 2021 to 2025
$2.4M
NIAID NIH HHS R01 AI019844NIAID NIH HHS R01 AI116933NIAID NIH HHS R01 AI156052NIAID NIH HHS R37 AI019844
6 · The paper itself

Abstract

Sporulation is an important feature of the clostridial life cycle, facilitating survival of these bacteria in harsh environments, contributing to disease transmission for pathogenic species, and sharing common early steps that are also involved in regulating industrially important solvent production by some non-pathogenic species. Initial genomics studies suggested that Clostridia lack the classical phosphorelay that phosphorylates Spo0A and initiates sporulation in

Indexed as

BacillusHistidineBacillus subtilisBacterial ProteinsClostridiumGene Expression Regulation, BacterialHistidine KinasePhosphorylationSpores, BacterialTranscription FactorsBacterial ProteinsHistidineHistidine KinaseTranscription FactorsClostridiahistidine kinasesphosphatasesSpo0Asporulation

Identifiers

PMID38477571
PMCPMC11210211
OpenAlexW4392895615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.