Evidence map›Paper›PMID 38477487›Full record

ArticleCancer medicine2024

Brain metastases in patients with salivary duct carcinoma: A retrospective study.

Chihiro Fushimi, Hideaki Takahashi, Daisuke Kawakita, Satoshi Kano, Kiyoaki Tsukahara, Hiroyuki Ozawa, Kenji Okami, Akihiro Sakai, Keisuke Yamazaki, Takuro Okada and 7 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 1 country.

Chihiro FushimiHead and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Hideaki TakahashiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, School of Medicine, Yokohama, Japan.
Daisuke KawakitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Satoshi KanoDepartment of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Hiroyuki OzawaDepartment of Otorhinolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Kenji OkamiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Akihiro SakaiDepartment of Otolaryngology Head and Neck Surgery, Tokai University School of Medicine, Isehara, Japan.
Keisuke YamazakiDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Takuro OkadaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
Toyoyuki HanazawaDepartment of Otolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Yuichiro SatoDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Yorihisa ImanishiOtorhinolaryngology, Head and Neck Surgery, International University of Health and Welfare, Narita Hospital, Chiba, Japan.
Akira ShimizuDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan.
Takashi MatsukiDepartment of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Kanagawa, Japan.ORCID 0000-0001-7633-3512
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Yuichiro TadaHead and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.ORCID 0000-0002-0159-8660
Tokyo Medical University · JPNiigata Cancer Center Hospital · JPTokai University · JPChiba University · JPHokkaido University · JPInternational University of Health and Welfare · JPKeio University · JPKitasato University · JPMita Hospital · JPNagoya City University · JPTokyo Medical University Hachioji Medical Center · JPTokyo National Hospital · JPYokohama City University · JP

Funding

JSPS Grants-in-Aid for Scientific Research (C) 20K07417JSPS Grants-in-Aid for Scientific Research (C) 20K07597JSPS Grants-in-Aid for Scientific Research (C) 21K09616JSPS Grants-in-Aid for Scientific Research (C) 21K16835
6 · The paper itself

Abstract

backgroundSalivary duct carcinoma (SDC) is a high-grade adenocarcinoma with a 5-year survival rate of 40%. Although drug therapy has improved patients' prognosis, the impact of brain metastasis (BM) remains poorly understood. We aimed to retrospectively examine the incidence of BM in patients with SDC (n = 464) and develop a tool to estimate their prognoses.

methodsWe retrospectively examined 464 patients with SDC enrolled in a multicenter study. We investigated the incidence of BM, overall survival (OS) rates, and factors affecting prognosis in patients with BM. We also developed an SDC-graded prognostic assessment (GPA) score for disease prognostication.

resultsSixty-five (14%) patients had BM. The median OS (mOS) was 13.1 months. On univariate and multivariate analyses, factors such as Eastern Cooperative Oncology Group Performance Status >1, human epidermal growth factor receptor 2-negative status, and locoregional uncontrolled disease were associated with poor OS. SDC-GPA scores according to the prognostic factors were 0, 1, 2, and 3 points, and mOS estimates were 50.5, 16.1, 3.9, and 1.2 months, respectively (p < 0.001).

conclusionThe SDC-GPA score emerged as a useful prognostication tool for patients with BM.

Indexed as

Brain NeoplasmsCarcinoma, DuctalSalivary Gland NeoplasmsHumansPrognosisRetrospective StudiesSalivary Ductsandrogen receptorbrain metastasesdistant metastaseshuman epidermal growth factor receptor 2salivary duct carcinoma

Identifiers

PMID38477487
PMCPMC10935879
OpenAlexW4392768594

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.