Evidence map›Paper›PMID 38477310›Full record

ArticleJournal of natural products2024

Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s.

Pritam Roy, Jonathan Maturano, Hale Hasdemir, Angel Lopez, Fengyun Xu, Judith Hellman, Emad Tajkhorshid, David Sarlah, Aditi Das

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Minor cannabinoids CBD, CBG, CBN, and CBC differentially modulate sensory neuron activation.The Journal of pharmacology and experimental therapeutics · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. α-Glucosidase Inhibitors from the Leaves ofJournal of agricultural and food chemistry · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pritam RoySchool of Chemistry and Biochemistry, College of Sciences, and Parker H. Petit Institute for Bioengineering and Biosciences (IBB), Georgia Institute of Technology (GaTech), Atlanta, Georgia 30332, United States.
Jonathan MaturanoRoger Adams Laboratory, Department of Chemistry, Cancer Center at Illinois, University of Illinois, Urbana, Illinois 61801, United States.
Hale HasdemirTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-9191-6062
Angel LopezSchool of Chemistry and Biochemistry, College of Sciences, and Parker H. Petit Institute for Bioengineering and Biosciences (IBB), Georgia Institute of Technology (GaTech), Atlanta, Georgia 30332, United States.
Fengyun XuJudith Hellman Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, United States.
Judith HellmanDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, United States.
Emad TajkhorshidTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-8434-1010
David SarlahRoger Adams Laboratory, Department of Chemistry, Cancer Center at Illinois, University of Illinois, Urbana, Illinois 61801, United States.ORCID 0000-0002-8736-8953
Aditi DasSchool of Chemistry and Biochemistry, College of Sciences, and Parker H. Petit Institute for Bioengineering and Biosciences (IBB), Georgia Institute of Technology (GaTech), Atlanta, Georgia 30332, United States.ORCID 0000-0002-6731-6726
University of Illinois Urbana-Champaign · USGeorgia Institute of Technology · USUniversity of California, San Francisco · US

Funding

Resource for Macromolecular Modeling and VisualizationR24GM145965 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Emad Tajkhorshid · 2022 to 2026
$6.2M
The study of Gpr149 in nociception and the peripheral action of minor cannabinoidsR01AT010757 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HELLMAN, JUDITH, SCHUMACHER, MARK A · 2019 to 2023
$3.0M
Biochemical Mechanism of Eicosanoid Synthesizing EnzymesR01GM115584 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI DAS, ADITI · 2017 to 2022
$1.7M
Systematic Investigation of Rare Cannabinoids with Pain ReceptorsR21AT010761 · NCCIH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI DAS, ADITI, SARLAH, DAVID · 2019 to 2020
$404k
NCCIH NIH HHS R01 AT010757NCCIH NIH HHS R21 AT010761NIGMS NIH HHS R01 GM115584NIGMS NIH HHS R24 GM145965
6 · The paper itself

Abstract

Cannabichromene (CBC) is a nonpsychoactive phytocannabinoid well-known for its wide-ranging health advantages. However, there is limited knowledge regarding its human metabolism following CBC consumption. This research aimed to explore the metabolic pathways of CBC by various human liver cytochrome P450 (CYP) enzymes and support the outcomes using

Indexed as

CannabinoidsCytochrome P-450 Enzyme SystemAnimalsCytochrome P-450 CYP2C9HumansMaleMiceMolecular Dynamics SimulationMolecular StructurecannabichromeneCannabinoidsCytochrome P-450 CYP2C9Cytochrome P-450 Enzyme System

Identifiers

PMID38477310
PMCPMC11061835
OpenAlexW4392749993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.