Evidence map›Paper›PMID 38477292›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

PET imaging of M4 muscarinic acetylcholine receptors in rhesus macaques using [

Vasily Belov, Nicolas J Guehl, Sridhar Duvvuri, Philip Iredale, Sung-Hyun Moon, Maeva Dhaynaut, Srinivas Chakilam, Alexander C MacDonagh, Peter A Rice, Daniel L Yokell and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. [Pharmacological reports : PR · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Vasily BelovGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sridhar DuvvuriCerevel Therapeutics, LLC, Cambridge, MA, USA.
Philip IredaleCerevel Therapeutics, LLC, Cambridge, MA, USA.
Sung-Hyun MoonGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Maeva DhaynautGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Srinivas ChakilamCerevel Therapeutics, LLC, Cambridge, MA, USA.
Alexander C MacDonaghGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peter A RiceGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daniel L YokellGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
John J RengerCerevel Therapeutics, LLC, Cambridge, MA, USA.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1645-523X
Harvard University · USCerevel Therapeutics (United States) · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Acquisition of a combined AFM/light microscope for research and educationS10OD010356 · OD · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2012 to 2012
$342k
NIBIB NIH HHS P41 EB022544NIH HHS S10 OD010356
6 · The paper itself

Abstract

Stimulation of the M

Indexed as

Macaca mulattaPositron-Emission TomographyReceptor, Muscarinic M4Allosteric RegulationAnimalsAzabicyclo CompoundsBrainCarbon RadioisotopesCyclic S-OxidesFemaleKineticsMaleRadiopharmaceuticals3-(1,4-diazabicyclo(3.2.2)nonan-4-yl)-6-fluorodibenzo(b,d)thiophene 5,5-dioxideAzabicyclo CompoundsCarbon RadioisotopesCyclic S-OxidesRadiopharmaceuticalsReceptor, Muscarinic M4[11C]MK-6884emraclidineM4 mAChRneuroimagingPAM

Identifiers

PMID38477292
PMCPMC11342722
OpenAlexW4392751036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.