Evidence map›Paper›PMID 38477254›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice.

Akiyo Natsubori, Soojin Kwon, Yoshiko Honda, Takashi Kojima, Akihiro Karashima, Kazuto Masamoto, Makoto Honda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Akiyo NatsuboriSleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0001-6401-4469
Soojin KwonSleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yoshiko HondaSleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Takashi KojimaSleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Akihiro KarashimaDepartment of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, Sendai, Japan.
Kazuto MasamotoDept. Mechanical and Intelligent Systems Engineering, Univ. of Electro-Communications, Tokyo, Japan.ORCID 0000-0002-2958-9627
Makoto HondaSleep Disorders Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Tokyo Metropolitan Institute of Medical Science · JPTohoku Institute of Technology · JPUniversity of Electro-Communications · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurovascular coupling (NVC) is the functional hyperemia of the brain responding to local neuronal activity. It is mediated by astrocytes and affected by subcortical ascending pathways in the cortex that convey information, such as sensory stimuli and the animal condition. Here, we investigate the influence of the raphe serotonergic system, a subcortical ascending arousal system in animals, on the modulation of cortical NVC and cerebral blood flow (CBF). Raphe serotonergic neurons were optogenically activated for 30 s, which immediately awakened the mice from non-rapid eye movement sleep. This caused a biphasic cortical hemodynamic change: a transient increase for a few seconds immediately after photostimulation onset, followed by a large progressive decrease during the stimulation period. Serotonergic neuron activation increased intracellular Ca

Indexed as

AstrocytesCerebrovascular CirculationHemodynamicsNeurovascular CouplingSerotonergic NeuronsSerotoninWakefulnessAnimalsCerebral CortexMaleMiceMice, Inbred C57BLRaphe NucleiSleepSerotoninAstrocytescerebral blood flowneurovascular couplingoptogeneticsserotonergic neurons

Identifiers

PMID38477254
PMCPMC11418750
OpenAlexW4392751034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.